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    Ppm1h protein phosphatase 1H (PP2C domain containing) [ Mus musculus (house mouse) ]

    Gene ID: 319468, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ppm1hprovided by MGI
    Official Full Name
    protein phosphatase 1H (PP2C domain containing)provided by MGI
    Primary source
    MGI:MGI:2442087
    See related
    Ensembl:ENSMUSG00000034613 AllianceGenome:MGI:2442087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARHCL1; A430075L18Rik; C030002B11Rik
    Summary
    Predicted to enable [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity and identical protein binding activity. Predicted to be involved in signal transduction. Is active in glutamatergic synapse. Is expressed in ganglia; liver lobe; spinal cord; and thymus primordium. Orthologous to human PPM1H (protein phosphatase, Mg2+/Mn2+ dependent 1H). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 12.2), kidney adult (RPKM 8.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppm1h in Genome Data Viewer
    Location:
    10 D2; 10 70.44 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (122512720..122781700)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (122677428..122945795)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36284 Neighboring gene STARR-seq mESC enhancer starr_28126 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:122088945-122089304 Neighboring gene predicted gene, 40793 Neighboring gene microRNA 6412 Neighboring gene STARR-seq mESC enhancer starr_28127 Neighboring gene microRNA 8104 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:122179315-122179468 Neighboring gene STARR-seq mESC enhancer starr_28129 Neighboring gene STARR-seq mESC enhancer starr_28131 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:122237487-122237748 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:122252171-122252412 Neighboring gene predicted gene, 36208 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:122283655-122283857 Neighboring gene predicted gene, 51817 Neighboring gene STARR-seq mESC enhancer starr_28140 Neighboring gene predicted gene, 51818 Neighboring gene STARR-positive B cell enhancer ABC_E8375 Neighboring gene STARR-positive B cell enhancer ABC_E5196 Neighboring gene STARR-positive B cell enhancer ABC_E9356 Neighboring gene STARR-positive B cell enhancer ABC_E10651 Neighboring gene microRNA let7i Neighboring gene MON2 homolog, regulator of endosome to Golgi trafficking

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain. Khan SS, et al. Elife, 2021 Oct 18. PMID 34658337, Free PMC Article
    2. Dual phosphorylation of protein phosphatase PPM1H promotes dephosphorylation of Smad1 in cellulo. Osawa J, et al. Biochem Biophys Res Commun, 2020 Sep 24. PMID 32600616
    3. N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells. Chida T, et al. Biochem J, 2013 Feb 1. PMID 23088624
    4. Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. Biesemann C, et al. EMBO J, 2014 Jan 13. PMID 24413018, Free PMC Article
    5. Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Coulpier F, et al. Glia, 2009 Oct. PMID 19243017

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dual phosphorylation of protein phosphatase PPM1H promotes dephosphorylation of Smad1 in cellulo.
      Title: Dual phosphorylation of protein phosphatase PPM1H promotes dephosphorylation of Smad1 in cellulo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 1H
    NP_001103688.1
    NP_795893.2
    XP_006513805.1
    XP_030100976.1
    XP_036011702.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110218.1 → NP_001103688.1  protein phosphatase 1H isoform 1

      See identical proteins and their annotated locations for NP_001103688.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC159503, AK043121, AK134804, AK220260, BP769253, CK622851
      Consensus CDS
      CCDS48705.1
      UniProtKB/Swiss-Prot
      Q3UD05, Q3UYC0, Q3V3H5, Q3V3Y7, Q571C9, Q7TMU7, Q8BYE6
      Related
      ENSMUSP00000066561.6, ENSMUST00000067918.12
      Conserved Domains (1) summary
      cd00143
      Location:142 → 506
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    2. NM_176919.4 → NP_795893.2  protein phosphatase 1H isoform 2

      See identical proteins and their annotated locations for NP_795893.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the 3' terminal exon and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK040194, AK040207, AK043121, AK220260
      Consensus CDS
      CCDS48706.1
      UniProtKB/Swiss-Prot
      Q3UYC0
      Related
      ENSMUSP00000124982.2, ENSMUST00000161487.8
      Conserved Domains (1) summary
      cd00143
      Location:142 → 462
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      122512720..122781700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245116.2 → XP_030100976.1  protein phosphatase 1H isoform X2

      Conserved Domains (1) summary
      cd00143
      Location:1 → 256
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    2. XM_036155809.1 → XP_036011702.1  protein phosphatase 1H isoform X2

      Conserved Domains (1) summary
      cd00143
      Location:1 → 256
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    3. XM_006513742.4 → XP_006513805.1  protein phosphatase 1H isoform X1

      Conserved Domains (1) summary
      cd00143
      Location:7 → 262
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RNA

    1. XR_004936202.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UYC0.1 GenPept UniProtKB/Swiss-Prot:Q3UYC0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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