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    Srpx2 sushi-repeat-containing protein, X-linked 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317181, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Srpx2provided by RGD
    Official Full Name
    sushi-repeat-containing protein, X-linked 2provided by RGD
    Primary source
    RGD:1562444
    See related
    EnsemblRapid:ENSRNOG00000003715 AllianceGenome:RGD:1562444
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562444
    Summary
    Predicted to enable hepatocyte growth factor binding activity; identical protein binding activity; and signaling receptor binding activity. Involved in positive regulation of synapse assembly. Located in cell surface; excitatory synapse; and synaptic membrane. Is active in glutamatergic synapse. Orthologous to human SRPX2 (sushi repeat containing protein X-linked 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 112.7), Heart (RPKM 42.8) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srpx2 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (101399748..101425486)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97106455..97132197)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (104734035..104760658)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene tenomodulin Neighboring gene tetraspanin 6 Neighboring gene synaptotagmin-like 4 Neighboring gene cleavage stimulation factor subunit 2 Neighboring gene NADPH oxidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Acute Downregulation of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 after Experimental Traumatic Brain Injury. Anwer M, et al. J Neurotrauma, 2020 Apr 1. PMID 31650880
    2. SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer. Tanaka K, et al. PLoS One, 2012. PMID 22242148, Free PMC Article
    3. SRPX2 is overexpressed in gastric cancer and promotes cellular migration and adhesion. Tanaka K, et al. Int J Cancer, 2009 Mar 1. PMID 19065654
    4. Two candidate downstream target genes for E2A-HLF. Kurosawa H, et al. Blood, 1999 Jan 1. PMID 9864177
    5. The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice. Sia GM, et al. Science, 2013 Nov 22. PMID 24179158, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Acute Downregulation of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 after Experimental Traumatic Brain Injury.
      Title: Acute Downregulation of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 after Experimental Traumatic Brain Injury.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hepatocyte growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hepatocyte growth factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vocalization behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in excitatory synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sushi repeat-containing protein SRPX2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108243.2 → NP_001101713.1  sushi repeat-containing protein SRPX2 precursor

      See identical proteins and their annotated locations for NP_001101713.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168975
      UniProtKB/Swiss-Prot
      B5DF94
      Conserved Domains (3) summary
      cd00033
      Location:265 → 320
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam02494
      Location:178 → 260
      HYR; HYR domain
      pfam13778
      Location:335 → 446
      DUF4174; Domain of unknown function (DUF4174)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      101399748..101425486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099720.2 → XP_038955648.1  sushi repeat-containing protein SRPX2 isoform X2

      Conserved Domains (3) summary
      cd00033
      Location:231 → 286
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam02494
      Location:114 → 196
      HYR; HYR domain
      pfam13778
      Location:301 → 420
      DUF4174; Domain of unknown function (DUF4174)

    2. XM_039099717.2 → XP_038955645.1  sushi repeat-containing protein SRPX2 isoform X1

      Related
      ENSRNOP00000085502.2, ENSRNOT00000103433.2
      Conserved Domains (3) summary
      cd00033
      Location:295 → 350
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam02494
      Location:178 → 260
      HYR; HYR domain
      pfam13778
      Location:365 → 484
      DUF4174; Domain of unknown function (DUF4174)

    3. XM_039099719.2 → XP_038955647.1  sushi repeat-containing protein SRPX2 isoform X1

      Conserved Domains (3) summary
      cd00033
      Location:295 → 350
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam02494
      Location:178 → 260
      HYR; HYR domain
      pfam13778
      Location:365 → 484
      DUF4174; Domain of unknown function (DUF4174)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5DF94.1 GenPept UniProtKB/Swiss-Prot:B5DF94

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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