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    Tmbim1 transmembrane BAX inhibitor motif containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316516, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tmbim1provided by RGD
    Official Full Name
    transmembrane BAX inhibitor motif containing 1provided by RGD
    Primary source
    RGD:1359409
    See related
    EnsemblRapid:ENSRNOG00000014797 AllianceGenome:RGD:1359409
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium channel activity and death receptor binding activity. Predicted to be involved in several processes, including negative regulation of Fas signaling pathway; negative regulation of apoptotic process; and positive regulation of blood vessel remodeling. Predicted to be located in endosome membrane and lysosomal membrane. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and membrane. Orthologous to human TMBIM1 (transmembrane BAX inhibitor motif containing 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Lung (RPKM 178.9), Testes (RPKM 90.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmbim1 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83320972..83338469, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (75871835..75889366, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81569289..81586469, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled bile acid receptor 1 Neighboring gene angio-associated, migratory cell protein Neighboring gene PNKD metallo-beta-lactamase domain containing Neighboring gene ciliogenesis associated TTC17 interacting protein Neighboring gene solute carrier family 11 member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface. Shukla S, et al. Apoptosis, 2011 Feb. PMID 21107705, Free PMC Article
    2. RECS1 deficiency in mice induces susceptibility to cystic medial degeneration. Zhao H, et al. Genes Genet Syst, 2006 Feb. PMID 16607040
    3. RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation. Zhao H, et al. Circ J, 2006 May. PMID 16636500
    4. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94053

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables death receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables death receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Fas signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Fas signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of blood vessel remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood vessel remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein lifeguard 3
    Names
    transmembrane BAX inhibitor motif-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007713.1 → NP_001007714.1  protein lifeguard 3

      See identical proteins and their annotated locations for NP_001007714.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079087
      UniProtKB/TrEMBL
      A0A0G2K356, A0A0G2K6F5, A0A9K3Y6R8, Q6AYE0
      Related
      ENSRNOP00000019848.6, ENSRNOT00000019848.7
      Conserved Domains (1) summary
      cd10428
      Location:87 → 306
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      83320972..83338469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083669.2 → XP_038939597.1  protein lifeguard 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K356, A0A0G2K6F5, A0A9K3Y6R8, Q6AYE0
      Conserved Domains (1) summary
      cd10428
      Location:87 → 306
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    2. XM_039083668.2 → XP_038939596.1  protein lifeguard 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K356, A0A0G2K6F5, A0A9K3Y6R8, Q6AYE0
      Conserved Domains (1) summary
      cd10428
      Location:87 → 306
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    3. XM_017596479.3 → XP_017451968.1  protein lifeguard 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K356, A0A0G2K6F5, A0A9K3Y6R8, Q6AYE0
      Conserved Domains (1) summary
      cd10428
      Location:87 → 306
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    4. XM_017596477.3 → XP_017451966.1  protein lifeguard 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K356, A0A0G2K6F5, A0A9K3Y6R8, Q6AYE0
      Conserved Domains (1) summary
      cd10428
      Location:87 → 306
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    5. XM_017596478.3 → XP_017451967.1  protein lifeguard 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K356, A0A0G2K6F5, A0A9K3Y6R8, Q6AYE0
      Conserved Domains (1) summary
      cd10428
      Location:87 → 306
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    6. XM_039083670.2 → XP_038939598.1  protein lifeguard 3 isoform X2

      Conserved Domains (1) summary
      cd10428
      Location:27 → 246
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    Nucleotide Protein Strain
    Heading Accession and Version

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