Panx3 pannexin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Panx3provided by RGD
Official Full Name: pannexin 3provided by RGD
Primary source: RGD:735137
See related: EnsemblRapid:ENSRNOG00000031675 AllianceGenome:RGD:735137
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium channel activity; gap junction hemi-channel activity; and structural molecule activity. Involved in cell-cell signaling. Predicted to be located in endoplasmic reticulum membrane and gap junction. Predicted to be active in plasma membrane. Orthologous to human PANX3 (pannexin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 4.2), Lung (RPKM 2.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (45554474..45566378, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (37366758..37377640, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (40126379..40137390, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis.
Title: Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis.
Pituitary gland expresses mRNA and protein transcripts of pannexins 1 and 2 but not pannexin 3.
Title: Expression and roles of pannexins in ATP release in the pituitary gland.
In the testis, Panx1 localized to the basal compartment of the seminiferous epithelium, while Panx3 was expressed in Leydig cells. In the ED, both Panxs were expressed in the apical region of ciliated cells.
Title: Characterization of pannexin1 and pannexin3 and their regulation by androgens in the male reproductive tract of the adult rat.
Panx1 and Panx3 are coexpressed in the mammalian epidermis, and the regulation of Panx1 plays a key role in keratinocyte differentiation.
Title: Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation.
although Panx1 and Panx3 share a common endoplasmic reticulum to Golgi secretory pathway to Cx43, their ultimate cell surface residency appears to be independent of cell contacts and the need for intact microtubules
Title: Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions.
Results show that pannexins 1, 2, and 3 are abundantly expressed in the mouse and rat cochlea and demonstrate distinct cellular distributions.
Title: Identification and characterization of pannexin expression in the mammalian cochlea.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables gap junction hemi-channel activity	ISO Inferred from Sequence Orthology more info
NOT enables gap junction hemi-channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables gap junction hemi-channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables structural molecule activity	ISS Inferred from Sequence or Structural Similarity more info
enables wide pore channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-1 production	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in gap junction	ISO Inferred from Sequence Orthology more info
located_in gap junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pannexin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.