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    Kbtbd3 kelch repeat and BTB domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315394, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Kbtbd3provided by RGD
    Official Full Name
    kelch repeat and BTB domain containing 3provided by RGD
    Primary source
    RGD:1310895
    See related
    EnsemblRapid:ENSRNOG00000069206 AllianceGenome:RGD:1310895
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KBTBD3 (kelch repeat and BTB domain containing 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Heart (RPKM 45.4), Kidney (RPKM 43.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kbtbd3 in Genome Data Viewer
    Location:
    8q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (9749229..9780036)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (1464162..1491144)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (1450345..1477250)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene MLV-related proviral Env polyprotein-like, pseudogene 5 Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Neighboring gene zinc finger protein 431 like, pseudogene 4 Neighboring gene Myb/SANT DNA binding domain containing 4 with coiled-coils

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch repeat and BTB domain-containing protein 3
    Names
    kelch repeat and BTB (POZ) domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108121.2 → NP_001101591.1  kelch repeat and BTB domain-containing protein 3

      See identical proteins and their annotated locations for NP_001101591.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KQJ4, D4A7F5
      Conserved Domains (3) summary
      PHA03098
      Location:38 → 595
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 385
      Kelch; KELCH repeat [structural motif]
      cd18271
      Location:24 → 153
      BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

    2. NM_001433311.1 → NP_001420240.1  kelch repeat and BTB domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KQJ4, D4A7F5

    3. NM_001433312.1 → NP_001420241.1  kelch repeat and BTB domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KQJ4, D4A7F5

    4. NM_001433313.1 → NP_001420242.1  kelch repeat and BTB domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KQJ4, D4A7F5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      9749229..9780036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242474.5 → XP_006242536.1  kelch repeat and BTB domain-containing protein 3 isoform X1

      Related
      ENSRNOP00000085465.1, ENSRNOT00000120313.2
      Conserved Domains (3) summary
      PHA03098
      Location:38 → 595
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 385
      Kelch; KELCH repeat [structural motif]
      cd18271
      Location:24 → 153
      BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

    2. XM_006242478.5 → XP_006242540.1  kelch repeat and BTB domain-containing protein 3 isoform X2

      Conserved Domains (6) summary
      smart00612
      Location:325 → 375
      Kelch; Kelch domain
      PHA03098
      Location:16 → 520
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:255 → 310
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:1 → 67
      BTB; BTB/POZ domain
      pfam01344
      Location:464 → 507
      Kelch_1; Kelch motif
      pfam07707
      Location:75 → 176
      BACK; BTB And C-terminal Kelch

    3. XM_006242477.5 → XP_006242539.1  kelch repeat and BTB domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006242539.1

      UniProtKB/TrEMBL
      A6KQJ4, D4A7F5
      Conserved Domains (3) summary
      PHA03098
      Location:38 → 595
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 385
      Kelch; KELCH repeat [structural motif]
      cd18271
      Location:24 → 153
      BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

    4. XM_006242476.4 → XP_006242538.1  kelch repeat and BTB domain-containing protein 3 isoform X1

      Conserved Domains (3) summary
      PHA03098
      Location:38 → 595
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 385
      Kelch; KELCH repeat [structural motif]
      cd18271
      Location:24 → 153
      BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

    5. XM_039081335.2 → XP_038937263.1  kelch repeat and BTB domain-containing protein 3 isoform X1

      Conserved Domains (3) summary
      PHA03098
      Location:38 → 595
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 385
      Kelch; KELCH repeat [structural motif]
      cd18271
      Location:24 → 153
      BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

    6. XM_039081336.2 → XP_038937264.1  kelch repeat and BTB domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A6KQJ4, D4A7F5
      Conserved Domains (3) summary
      PHA03098
      Location:38 → 595
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 385
      Kelch; KELCH repeat [structural motif]
      cd18271
      Location:24 → 153
      BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
    Nucleotide Protein Strain
    Heading Accession and Version

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