Tmprss6 transmembrane serine protease 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmprss6provided by RGD
Official Full Name: transmembrane serine protease 6provided by RGD
Primary source: RGD:1307138
See related: EnsemblRapid:ENSRNOG00000000184 AllianceGenome:RGD:1307138
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including membrane protein proteolysis; regulation of transcription by RNA polymerase II; and self proteolysis. Predicted to act upstream of or within multicellular organismal-level iron ion homeostasis and negative regulation of BMP signaling pathway. Predicted to be located in extracellular space. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in microcytic anemia. Orthologous to human TMPRSS6 (transmembrane serine protease 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 723.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (111871504..111902127, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (109991008..110021626, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (119659323..119689953, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EPO administration increased TMPRSS6 content in the plasma membrane-enriched fraction of liver homogenate; in iron-pretreated rats, this increase was abolished. The results confirm that iron pretreatment prevents the EPO-induced decrease in liver Hamp expression.
Title: Erythropoietin administration increases splenic erythroferrone protein content and liver TMPRSS6 protein content in rats.
Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression
Title: Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.
identification, structural features, enzymology, expression pattern and potential roles of TMPRSS6 [review]
Title: The type II transmembrane serine protease matriptase-2--identification, structural features, enzymology, expression pattern and potential roles.

Submit: New GeneRIF Correction

General gene information

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Markers

RH135327 (e-PCR)
- UniSTS:218604

D3Rat170 (e-PCR), detects polymorphism
- UniSTS:227570

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in self proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protease serine 6

Names: transmembrane protease, serine 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130556.1 → NP_001124028.1 transmembrane protease serine 6

See identical proteins and their annotated locations for NP_001124028.1

Status: PROVISIONAL

Source sequence(s)

CH473950

UniProtKB/TrEMBL

A0A8I6ANM9, A6HSK5, D3ZF49

Related

ENSRNOP00000000200.5, ENSRNOT00000000200.8

Conserved Domains (5) summary

smart00020
Location:576 → 772

Tryp_SPc; Trypsin-like serine protease

cd00112
Location:495 → 525

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:577 → 771

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00057
Location:529 → 566

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam01390
Location:88 → 185

SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

111871504..111902127 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241996.5 → XP_006242058.1 transmembrane protease serine 6 isoform X2

UniProtKB/TrEMBL

A0A8I6ANM9, A0A8I6G6J0

Conserved Domains (5) summary

smart00020
Location:564 → 794

Tryp_SPc; Trypsin-like serine protease

cd00112
Location:483 → 513

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:565 → 797

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00057
Location:517 → 554

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam01390
Location:76 → 173

SEA; SEA domain
XM_006241995.5 → XP_006242057.1 transmembrane protease serine 6 isoform X1

See identical proteins and their annotated locations for XP_006242057.1

UniProtKB/TrEMBL

A0A8I6ANM9, A6HSK7

Related

ENSRNOP00000080392.2, ENSRNOT00000097438.2

Conserved Domains (5) summary

smart00020
Location:576 → 806

Tryp_SPc; Trypsin-like serine protease

cd00112
Location:495 → 525

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:577 → 809

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00057
Location:529 → 566

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam01390
Location:88 → 185

SEA; SEA domain