Naprt nicotinate phosphoribosyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Naprtprovided by RGD
Official Full Name: nicotinate phosphoribosyltransferaseprovided by RGD
Primary source: RGD:1302945
See related: EnsemblRapid:ENSRNOG00000007939 AllianceGenome:RGD:1302945
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Naprt1
Summary: Enables nicotinate phosphoribosyltransferase activity. Involved in NAD biosynthetic process. Predicted to be active in cytosol. Orthologous to human NAPRT (nicotinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 1069.3), Liver (RPKM 336.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (109457328..109460817, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (107576645..107580102, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (116922979..116926436, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD
Title: Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH143647 (e-PCR)
- UniSTS:232893

AI410930 (e-PCR)
- UniSTS:250569

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nicotinate phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinate phosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables nicotinate phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nicotinate phosphoribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables nicotinate phosphoribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in NAD salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nicotinate phosphoribosyltransferase

Names: NAPRTase; nicotinate phosphoribosyltransferase domain containing 1; nicotinate phosphoribosyltransferase domain-containing protein 1; nicotinate phosphoribosyltransferase-like protein

NP_997492.2

EC 6.3.4.21

XP_038935166.1

EC 6.3.4.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207609.2 → NP_997492.2 nicotinate phosphoribosyltransferase

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q6XQN1

UniProtKB/TrEMBL

A6HS25, G3V709

Related

ENSRNOP00000010637.4, ENSRNOT00000010637.7

Conserved Domains (1) summary

cl21457
Location:13 → 525

TIM; TIM-like beta/alpha barrel domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

109457328..109460817 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079238.2 → XP_038935166.1 nicotinate phosphoribosyltransferase isoform X1

Conserved Domains (1) summary

cl21457
Location:21 → 356

TIM; TIM-like beta/alpha barrel domains