Cmpk2 cytidine/uridine monophosphate kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cmpk2provided by RGD
Official Full Name: cytidine/uridine monophosphate kinase 2provided by RGD
Primary source: RGD:1305881
See related: EnsemblRapid:ENSRNOG00000007690 AllianceGenome:RGD:1305881
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tyki
Summary: Enables UMP/dUMP kinase activity and thymidylate kinase activity. Involved in dTDP biosynthetic process and dUDP biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human CMPK2 (cytidine/uridine monophosphate kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 94.5), Lung (RPKM 48.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (48802150..48813652)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (43073706..43085183)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (45683242..45694824)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Electroacupuncture Inhibits NLRP3 Activation by Regulating CMPK2 After Spinal Cord Injury.
Title: Electroacupuncture Inhibits NLRP3 Activation by Regulating CMPK2 After Spinal Cord Injury.

Submit: New GeneRIF Correction

General gene information

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Markers

RH133559 (e-PCR)
- UniSTS:216842

BE101246 (e-PCR)
- UniSTS:243536

RH141869 (e-PCR)
- UniSTS:223861

RH134277 (e-PCR)
- UniSTS:217559

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (d)CMP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables (d)CMP kinase activity	ISO Inferred from Sequence Orthology more info
enables UMP kinase activity	ISO Inferred from Sequence Orthology more info
enables UMP/dUMP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables thymidylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thymidylate kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in dTDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dTDP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dTTP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dUDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dUDP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: UMP-CMP kinase 2, mitochondrial

Names: cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; thymidylate kinase family LPS-inducible member

NP_001101487.1

EC 2.7.4.14

XP_063117965.1

EC 2.7.4.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108017.1 → NP_001101487.1 UMP-CMP kinase 2, mitochondrial

See identical proteins and their annotated locations for NP_001101487.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/TrEMBL

A6HB00, D3ZC63

Related

ENSRNOP00000102136.1, ENSRNOT00000133443.1

Conserved Domains (1) summary

cl17190
Location:225 → 413

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...