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    SmydA-8 SET and MYND domain containing, arthropod-specific, member 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31200, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SmydA-8provided by FlyBase
    Official Full Name
    SET and MYND domain containing, arthropod-specific, member 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0053548
    Locus tag
    Dmel_CG33548
    See related
    AllianceGenome:FB:FBgn0053548
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18033; CG32799; CG32800; CG33548; Dmel\CG33548; EG:103B4.4; EG:103B4.5; msta; Msta; MSTA
    Summary
    Predicted to enable S-adenosylmethionine-dependent methyltransferase activity and histone deacetylase binding activity. Predicted to be involved in histone lysine methylation and negative regulation of gene expression. Predicted to be located in chromatin. Is expressed in eye; photoreceptor cell; and spermatozoon. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See SmydA-8 in Genome Data Viewer
    Location:
    2E2-2E2; 1-0.8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2205515..2213809, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2099548..2107842, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Monocarboxylate transporter 1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43637 Neighboring gene Fatty acyl-CoA reductase in oenocytes Neighboring gene Vinculin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Germline transformation of Drosophila melanogaster with the piggyBac transposon vector. Handler AM, et al. Insect Mol Biol, 1999 Nov. PMID 10634970
    2. Alternative mechanisms for talin to mediate integrin function. Klapholz B, et al. Curr Biol, 2015 Mar 30. PMID 25754646, Free PMC Article
    3. Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species. Calpena E, et al. PLoS One, 2015. PMID 26230726, Free PMC Article
    4. A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. Thompson EC, et al. PLoS One, 2008 Aug 20. PMID 18714374, Free PMC Article
    5. CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells. Xu Y, et al. J Cell Sci, 2016 Jan 15. PMID 26598556, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone deacetylase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SET and MYND domain containing, arthropod-specific, member 8
    Names
    CG33548-PA
    CG33548-PB
    CG33548-PC
    CG33548-PD
    SmydA-8-PA
    SmydA-8-PB
    SmydA-8-PC
    SmydA-8-PD
    msta

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2205515..2213809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297883.1 → NP_001284812.1  SET and MYND domain containing, arthropod-specific, member 8, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284812.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46040, O46041, Q9UB82
      UniProtKB/TrEMBL
      B5RJI3, X2JDK3
      Conserved Domains (1) summary
      smart00317
      Location:189 → 293
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    2. NM_001014718.2 → NP_001014718.1  SET and MYND domain containing, arthropod-specific, member 8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014718.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83501
      Conserved Domains (1) summary
      smart00317
      Location:199 → 279
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    3. NM_001297882.1 → NP_001284811.1  SET and MYND domain containing, arthropod-specific, member 8, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284811.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JI38

    4. NM_001014717.2 → NP_001014717.1  SET and MYND domain containing, arthropod-specific, member 8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014717.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46040, O46041, Q9UB82
      UniProtKB/TrEMBL
      B5RJI3, X2JDK3
      Conserved Domains (1) summary
      smart00317
      Location:189 → 293
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46040.3 O46040
    P83501.2 P83501
    X2JDK3 X2JDK3
    X2JI38 X2JI38

    Gene LinkOut

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