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    Ak8 adenylate kinase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311833, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ak8provided by RGD
    Official Full Name
    adenylate kinase 8provided by RGD
    Primary source
    RGD:1303144
    See related
    EnsemblRapid:ENSRNOG00000012761 AllianceGenome:RGD:1303144
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AK 8; RGD1303144
    Summary
    Predicted to enable AMP binding activity and nucleobase-containing compound kinase activity. Predicted to be involved in nucleoside monophosphate phosphorylation and phosphorylation. Predicted to act upstream of or within ventricular system development. Predicted to be located in axoneme and sperm flagellum. Predicted to be active in cytoplasm. Orthologous to human AK8 (adenylate kinase 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 261.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ak8 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (32426892..32542432)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (12028895..12144468)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (7279429..7394509)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene TSC complex subunit 1 Neighboring gene sperm acrosome associated 9 Neighboring gene RNA, U1 small nuclear 136 Neighboring gene general transcription factor IIIC subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Adenine nucleotide metabolism and a role for AMP in modulating flagellar waveforms in mouse sperm. Vadnais ML, et al. Biol Reprod, 2014 Jun. PMID 24740601, Free PMC Article
    2. The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes. Panayiotou C, et al. Biochem J, 2011 Feb 1. PMID 21080915
    3. Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein. Van Rompay AR, et al. Eur J Biochem, 1999 Apr. PMID 10215863
    4. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. Amiri M, et al. Int J Biochem Cell Biol, 2013 May. PMID 23416111
    5. Congenital hydrocephalus in genetically engineered mice. Vogel P, et al. Vet Pathol, 2012 Jan. PMID 21746835

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94995

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables (d)CMP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables (d)CMP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables AMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenylate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside diphosphate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ventricular system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in 9+2 motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenylate kinase 8
    Names
    ATP-AMP transphosphorylase 8
    HypB, AroK, ADK and rho factor domain containing protein RGD1303144
    putative adenylate kinase-like protein C9orf98 homolog
    NP_001004266.1
    XP_006233856.1
    XP_017447314.1
    XP_017447315.1
    XP_017447316.1
    XP_038961149.1
    XP_038961150.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004266.1 → NP_001004266.1  adenylate kinase 8

      See identical proteins and their annotated locations for NP_001004266.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079446
      UniProtKB/Swiss-Prot
      Q68FP8
      UniProtKB/TrEMBL
      A6JTP9
      Related
      ENSRNOP00000017029.4, ENSRNOT00000017029.7
      Conserved Domains (2) summary
      cd01428
      Location:270 → 462
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:270 → 468
      adk; adenylate kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      32426892..32542432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591827.3 → XP_017447316.1  adenylate kinase 8 isoform X1

      UniProtKB/TrEMBL
      A6JTQ0
      Conserved Domains (2) summary
      cd01428
      Location:241 → 433
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:241 → 439
      adk; adenylate kinase

    2. XM_017591826.3 → XP_017447315.1  adenylate kinase 8 isoform X1

      UniProtKB/TrEMBL
      A6JTQ0
      Conserved Domains (2) summary
      cd01428
      Location:241 → 433
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:241 → 439
      adk; adenylate kinase

    3. XM_006233794.5 → XP_006233856.1  adenylate kinase 8 isoform X1

      See identical proteins and their annotated locations for XP_006233856.1

      UniProtKB/TrEMBL
      A6JTQ0
      Conserved Domains (2) summary
      cd01428
      Location:241 → 433
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:241 → 439
      adk; adenylate kinase

    4. XM_039105221.2 → XP_038961149.1  adenylate kinase 8 isoform X2

      Conserved Domains (2) summary
      cd01428
      Location:270 → 369
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      pfam17819
      Location:9 → 48
      DUF5582; Family of unknown function (DUF5582)

    5. XM_039105222.2 → XP_038961150.1  adenylate kinase 8 isoform X3

      Conserved Domains (2) summary
      cd01428
      Location:270 → 369
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      pfam17819
      Location:9 → 48
      DUF5582; Family of unknown function (DUF5582)

    6. XM_017591825.3 → XP_017447314.1  adenylate kinase 8 isoform X1

      UniProtKB/TrEMBL
      A6JTQ0
      Related
      ENSRNOP00000102612.1, ENSRNOT00000147118.1
      Conserved Domains (2) summary
      cd01428
      Location:241 → 433
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:241 → 439
      adk; adenylate kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FP8.1 GenPept UniProtKB/Swiss-Prot:Q68FP8

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