Neurl2 neuralized E3 ubiquitin protein ligase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Neurl2provided by RGD
Official Full Name: neuralized E3 ubiquitin protein ligase 2provided by RGD
Primary source: RGD:1306409
See related: EnsemblRapid:ENSRNOG00000015797 AllianceGenome:RGD:1306409
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to act upstream of or within sarcomere organization. Predicted to be located in muscle tendon junction. Predicted to be part of VCB complex. Orthologous to human NEURL2 (neuralized E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 133.2), Heart (RPKM 91.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (173985996..173988717, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (153566659..153569380, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (161296303..161299024, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myofibril assembly	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sarcomere organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of VCB complex	ISO Inferred from Sequence Orthology more info
located_in muscle tendon junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuralized-like protein 2

Names: neuralized homolog 2; neuralized-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107802.2 → NP_001101272.1 neuralized-like protein 2

See identical proteins and their annotated locations for NP_001101272.1

Status: VALIDATED

Source sequence(s)

BC158617

UniProtKB/TrEMBL

A6JXC1, B0BMZ0, F7FB77

Conserved Domains (2) summary

smart00969
Location:249 → 285

SOCS_box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases

cd12887
Location:25 → 242

SPRY_NHR_like; SPRY domain in neuralized homology repeat