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    Ccm2l CCM2 like scaffold protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311550, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Ccm2lprovided by RGD
    Official Full Name
    CCM2 like scaffold proteinprovided by RGD
    Primary source
    RGD:1305202
    See related
    EnsemblRapid:ENSRNOG00000009191 AllianceGenome:RGD:1305202
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305202
    Summary
    Predicted to be involved in heart morphogenesis. Predicted to act upstream of or within several processes, including heart development; negative regulation of homotypic cell-cell adhesion; and positive regulation of fibroblast growth factor production. Orthologous to human CCM2L (CCM2 like scaffold protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 56.1), Heart (RPKM 22.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccm2l in Genome Data Viewer
    Location:
    3q41
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (161993717..162009372)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141533470..141549136)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148541404..148557464)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene p53 and DNA damage regulated 1 Neighboring gene XK related 7 Neighboring gene uncharacterized LOC108350503 Neighboring gene HCK proto-oncogene, Src family tyrosine kinase Neighboring gene uncharacterized LOC102554664 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. Zheng X, et al. Dev Cell, 2012 Aug 14. PMID 22898778, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac atrium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac muscle tissue growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of homotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of homotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of fibroblast growth factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular trabecula myocardium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cerebral cavernous malformations 2 protein-like
    Names
    CCM2 like scaffolding protein
    cerebral cavernous malformation 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      161993717..162009372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106863.2 → XP_038962791.1  cerebral cavernous malformations 2 protein-like isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSU2
      Related
      ENSRNOP00000081530.1, ENSRNOT00000120254.2
      Conserved Domains (2) summary
      cd13166
      Location:41 → 340
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:399 → 489
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    2. XM_039106864.2 → XP_038962792.1  cerebral cavernous malformations 2 protein-like isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSU2
      Conserved Domains (2) summary
      cd13166
      Location:41 → 340
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:399 → 489
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    3. XM_008762395.4 → XP_008760617.2  cerebral cavernous malformations 2 protein-like isoform X4

      UniProtKB/TrEMBL
      D3ZAM4
      Related
      ENSRNOP00000012187.7, ENSRNOT00000012187.8
      Conserved Domains (1) summary
      cd13166
      Location:41 → 340
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe

    4. XM_039106866.2 → XP_038962794.1  cerebral cavernous malformations 2 protein-like isoform X3

      Conserved Domains (1) summary
      cd13166
      Location:41 → 340
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe

    5. XM_039106865.2 → XP_038962793.1  cerebral cavernous malformations 2 protein-like isoform X2

      Conserved Domains (2) summary
      cd13166
      Location:1 → 299
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:358 → 448
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    RNA

    1. XR_010064998.1 RNA Sequence

    2. XR_005502970.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
    Research Materials