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    Pak5 p21 (RAC1) activated kinase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311450, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pak5provided by RGD
    Official Full Name
    p21 (RAC1) activated kinase 5provided by RGD
    Primary source
    RGD:1312009
    See related
    EnsemblRapid:ENSRNOG00000005509 AllianceGenome:RGD:1312009
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pak7; PAK-5; PAK-7
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cellular response to starvation; intracellular signal transduction; and regulation of MAPK cascade. Predicted to act upstream of or within learning or memory; locomotory behavior; and negative regulation of extrinsic apoptotic signaling pathway. Predicted to be located in cytosol; mitochondrion; and nucleus. Predicted to be active in cytoplasm and synapse. Orthologous to human PAK5 (p21 (RAC1) activated kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 102.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pak5 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (143848404..144156674, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (123395678..123703967, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (129042232..129357512, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene lysosomal-associated membrane protein family, member 5 Neighboring gene small Cajal body-specific RNA 4 like 2 Neighboring gene uncharacterized LOC134486160 Neighboring gene uncharacterized LOC108350472 Neighboring gene ankyrin repeat and EF-hand domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. Furnari MA, et al. PLoS One, 2013. PMID 23593460, Free PMC Article
    2. Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Nekrasova T, et al. Dev Biol, 2008 Oct 1. PMID 18675265
    3. An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Morris DW, et al. Hum Mol Genet, 2014 Jun 15. PMID 24474471, Free PMC Article
    4. p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Cotteret S, et al. Mol Cell Biol, 2003 Aug. PMID 12897128, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 5
    Names
    p21 (CDKN1A)-activated kinase 7
    p21 (RAC1) activated kinase 7
    p21 protein (Cdc42/Rac)-activated kinase 7
    p21-activated kinase 5
    p21-activated kinase 7
    serine/threonine-protein kinase PAK 7
    NP_001101251.1
    XP_017447245.1
    XP_017447246.1
    XP_038960946.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107781.2 → NP_001101251.1  serine/threonine-protein kinase PAK 5

      See identical proteins and their annotated locations for NP_001101251.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      D4A280
      Related
      ENSRNOP00000007410.3, ENSRNOT00000007410.6
      Conserved Domains (2) summary
      cd06658
      Location:425 → 716
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:9 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    2. NM_001434030.1 → NP_001420959.1  serine/threonine-protein kinase PAK 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001434031.1 → NP_001420960.1  serine/threonine-protein kinase PAK 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      143848404..144156674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591756.3 → XP_017447245.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      D4A280
      Conserved Domains (2) summary
      cd06658
      Location:425 → 716
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:9 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    2. XM_039105018.2 → XP_038960946.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      D4A280
      Conserved Domains (2) summary
      cd06658
      Location:425 → 716
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:9 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    3. XM_017591757.3 → XP_017447246.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      D4A280
      Conserved Domains (2) summary
      cd06658
      Location:425 → 716
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:9 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4A280.1 GenPept UniProtKB/Swiss-Prot:D4A280

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