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    Cep152 centrosomal protein 152 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311391, updated on 2-Nov-2024

    Summary

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    Symbol
    Cep152provided by RGD
    Full Name
    centrosomal protein 152provided by RGD
    Primary source
    RGD:1305348
    See related
    EnsemblRapid:ENSRNOG00000065817 AllianceGenome:RGD:1305348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305348
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in centriole replication and de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Predicted to be located in several cellular components, including deuterosome; microtubule organizing center; and procentriole. Predicted to be part of procentriole replication complex. Human ortholog(s) of this gene implicated in Seckel syndrome 5 and primary autosomal recessive microcephaly 9. Orthologous to human CEP152 (centrosomal protein 152). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 36.2), Spleen (RPKM 27.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep152 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (133243979..133332271, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (112803185..112878298, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (117822799..117894856, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene uncharacterized LOC120101649 Neighboring gene fibrillin 1 Neighboring gene uncharacterized LOC120101652 Neighboring gene 40S ribosomal protein S14-like Neighboring gene SHC adaptor protein 4 Neighboring gene EP300 interacting inhibitor of differentiation 1 Neighboring gene SECIS binding protein 2-like Neighboring gene TATA element modulatory factor 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Kalay E, et al. Nat Genet, 2011 Jan. PMID 21131973, Free PMC Article
    2. Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome. Cizmecioglu O, et al. J Cell Biol, 2010 Nov 15. PMID 21059844, Free PMC Article
    3. The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. Tang CJ, et al. EMBO J, 2011 Oct 21. PMID 22020124, Free PMC Article
    4. The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Zhao H, et al. Nat Cell Biol, 2013 Dec. PMID 24240477
    5. MDM1 is a microtubule-binding protein that negatively regulates centriole duplication. Van de Mark D, et al. Mol Biol Cell, 2015 Nov 1. PMID 26337392, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in deuterosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in procentriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of procentriole replication complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 152 kDa
    Names
    centrosomal protein 152kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427266.1 → NP_001414195.1  centrosomal protein of 152 kDa

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZRX6
      Related
      ENSRNOP00000079893.2, ENSRNOT00000105077.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      133243979..133332271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106547.2 → XP_038962475.1  centrosomal protein of 152 kDa isoform X2

      Conserved Domains (3) summary
      PTZ00121
      Location:638 → 1090
      PTZ00121; MAEBL; Provisional
      PRK12704
      Location:1200 → 1387
      PRK12704; phosphodiesterase; Provisional
      TIGR02168
      Location:235 → 985
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_039106550.2 → XP_038962478.1  centrosomal protein of 152 kDa isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:625 → 1351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:236 → 939
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_039106551.2 → XP_038962479.1  centrosomal protein of 152 kDa isoform X7

      Conserved Domains (3) summary
      PTZ00121
      Location:571 → 1023
      PTZ00121; MAEBL; Provisional
      PRK12704
      Location:1133 → 1320
      PRK12704; phosphodiesterase; Provisional
      TIGR02168
      Location:168 → 918
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_039106548.2 → XP_038962476.1  centrosomal protein of 152 kDa isoform X3

      Related
      ENSRNOP00000109904.1, ENSRNOT00000124472.1
      Conserved Domains (3) summary
      PTZ00121
      Location:639 → 1091
      PTZ00121; MAEBL; Provisional
      PRK12704
      Location:1201 → 1388
      PRK12704; phosphodiesterase; Provisional
      TIGR02168
      Location:236 → 986
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_039106546.2 → XP_038962474.1  centrosomal protein of 152 kDa isoform X1

      Conserved Domains (3) summary
      PTZ00121
      Location:639 → 1091
      PTZ00121; MAEBL; Provisional
      PRK12704
      Location:1201 → 1388
      PRK12704; phosphodiesterase; Provisional
      TIGR02168
      Location:236 → 986
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_063283746.1 → XP_063139816.1  centrosomal protein of 152 kDa isoform X5

    7. XM_008762222.4 → XP_008760444.2  centrosomal protein of 152 kDa isoform X4

      Conserved Domains (3) summary
      PTZ00121
      Location:617 → 1069
      PTZ00121; MAEBL; Provisional
      PRK12704
      Location:1179 → 1376
      PRK12704; phosphodiesterase; Provisional
      TIGR02168
      Location:235 → 964
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_039106552.2 → XP_038962480.1  centrosomal protein of 152 kDa isoform X8

      Conserved Domains (3) summary
      PTZ00121
      Location:436 → 888
      PTZ00121; MAEBL; Provisional
      PRK12704
      Location:998 → 1195
      PRK12704; phosphodiesterase; Provisional
      TIGR02168
      Location:33 → 783
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_063283748.1 → XP_063139818.1  centrosomal protein of 152 kDa isoform X10

    10. XM_039106553.2 → XP_038962481.1  centrosomal protein of 152 kDa isoform X9

      Conserved Domains (3) summary
      PTZ00121
      Location:411 → 863
      PTZ00121; MAEBL; Provisional
      PRK12704
      Location:973 → 1170
      PRK12704; phosphodiesterase; Provisional
      TIGR02168
      Location:8 → 758
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    11. XM_039106557.2 → XP_038962485.1  centrosomal protein of 152 kDa isoform X11

      Conserved Domains (2) summary
      PTZ00121
      Location:639 → 1091
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:198 → 829
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_010064629.1 RNA Sequence

    2. XR_010064628.1 RNA Sequence

    3. XR_010064627.1 RNA Sequence

    4. XR_010064630.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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