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    Dusp19 dual specificity phosphatase 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311151, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dusp19provided by RGD
    Official Full Name
    dual specificity phosphatase 19provided by RGD
    Primary source
    RGD:1307457
    See related
    AllianceGenome:RGD:1307457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including phosphoprotein phosphatase activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in negative regulation of JUN kinase activity; positive regulation of JNK cascade; and positive regulation of JUN kinase activity. Predicted to act upstream of or within JNK cascade; negative regulation of MAPK cascade; and protein dephosphorylation. Predicted to be active in cytoplasm. Orthologous to human DUSP19 (dual specificity phosphatase 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 55.6), Lung (RPKM 40.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dusp19 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (85945289..86081289)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (65538424..65554465)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (67849966..67862475)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486397 Neighboring gene NCK-associated protein 1 Neighboring gene small nucleolar RNA U3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene nucleoporin 35 Neighboring gene torsin 1A interacting protein 2 like 1 Neighboring gene uncharacterized LOC120101446

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DUSP19 regulates IL-1β-induced apoptosis and MMPs expression in rat chondrocytes through JAK2/STAT3 signaling pathway. Yao ZZ, et al. Biomed Pharmacother, 2017 Dec. PMID 29174854
    2. DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis. Wang Y, et al. Mol Biosyst, 2016 Mar. PMID 26751999
    3. A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway. Zama T, et al. J Biol Chem, 2002 Jun 28. PMID 11959861
    4. Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. Zama T, et al. J Biol Chem, 2002 Jun 28. PMID 11959862
    5. A growing family of dual specificity phosphatases with low molecular masses. Aoki N, et al. J Biochem, 2001 Jul. PMID 11432789

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DSP19 up-regulation inhibited IL-1beta-induced chondrocytes apoptosis and MMPs expression through inactivating JAK2/STAT3 pathway.
      Title: DUSP19 regulates IL-1β-induced apoptosis and MMPs expression in rat chondrocytes through JAK2/STAT3 signaling pathway.
    2. the activity of JNK stimulated by leptin was suppressed by DUSP19 overexpression.
      Title: DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables JUN kinase phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables JUN kinase phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP-kinase scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mitogen-activated protein kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 19
    NP_001101209.2
    XP_038960797.1
    XP_063139714.1
    XP_063139715.1
    XP_063139716.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107739.2 → NP_001101209.2  dual specificity protein phosphatase 19

      See identical proteins and their annotated locations for NP_001101209.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMN2
      Conserved Domains (1) summary
      cd00127
      Location:64 → 199
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      85945289..86081289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104869.2 → XP_038960797.1  dual specificity protein phosphatase 19 isoform X4

      Conserved Domains (1) summary
      cl28904
      Location:64 → 105
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_063283645.1 → XP_063139715.1  dual specificity protein phosphatase 19 isoform X2

    3. XM_063283646.1 → XP_063139716.1  dual specificity protein phosphatase 19 isoform X3

    4. XM_063283644.1 → XP_063139714.1  dual specificity protein phosphatase 19 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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