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    Alpk1 alpha-kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310879, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Alpk1provided by RGD
    Official Full Name
    alpha-kinase 1provided by RGD
    Primary source
    RGD:1304613
    See related
    EnsemblRapid:ENSRNOG00000022636 AllianceGenome:RGD:1304613
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304613
    Summary
    Predicted to enable monosaccharide binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cilium assembly; cytoplasmic pattern recognition receptor signaling pathway; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within response to bacterium. Predicted to be located in cytosol; microtubule cytoskeleton; and photoreceptor connecting cilium. Orthologous to human ALPK1 (alpha kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 49.6), Heart (RPKM 42.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Alpk1 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (218801425..218924013, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (216126939..216247180, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (231997360..232117471, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485763 Neighboring gene neurogenin 2 Neighboring gene ribosomal protein L29, pseudogene 5 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 like 2 Neighboring gene TRAF-interacting protein with forkhead-associated domain Neighboring gene adaptor-related protein complex 1 associated regulatory protein Neighboring gene transfer RNA alanine (anticodon AGC) 70

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System. Zimmermann S, et al. Cell Rep, 2017 Sep 5. PMID 28877472
    2. ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria. Milivojevic M, et al. PLoS Pathog, 2017 Feb. PMID 28222186, Free PMC Article
    3. Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose. Zhou P, et al. Nature, 2018 Sep. PMID 30111836
    4. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic pattern recognition receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor connecting cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-kinase 1; alpha-protein kinase 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433149.1 → NP_001420078.1  alpha-kinase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    2. NM_001433150.1 → NP_001420079.1  alpha-kinase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D3ZTA7

    3. NM_001433151.1 → NP_001420080.1  alpha-kinase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      218801425..218924013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104062.2 → XP_038959990.1  alpha-protein kinase 1 isoform X2

      UniProtKB/TrEMBL
      A6HVL8
      Conserved Domains (1) summary
      cd16969
      Location:1022 → 1248
      Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1

    2. XM_039104061.2 → XP_038959989.1  alpha-protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      A6HVL8
      Conserved Domains (1) summary
      cd16969
      Location:1054 → 1280
      Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1

    3. XM_017591342.3 → XP_017446831.1  alpha-protein kinase 1 isoform X1

      Related
      ENSRNOP00000107422.1, ENSRNOT00000155515.1
      Conserved Domains (1) summary
      cd16969
      Location:1054 → 1280
      Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1

    4. XM_063282918.1 → XP_063138988.1  alpha-protein kinase 1 isoform X4

      Related
      ENSRNOP00000104468.1, ENSRNOT00000124085.1

    5. XM_227715.10 → XP_227715.5  alpha-protein kinase 1 isoform X3

      Related
      ENSRNOP00000108175.1, ENSRNOT00000144166.1
      Conserved Domains (1) summary
      smart00811
      Location:1007 → 1215
      Alpha_kinase; Alpha-kinase family
    Nucleotide Protein Strain
    Heading Accession and Version

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