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    Eif5a2 eukaryotic translation initiation factor 5A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310261, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Eif5a2provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 5A2provided by RGD
    Primary source
    RGD:1306196
    See related
    EnsemblRapid:ENSRNOG00000011859 AllianceGenome:RGD:1306196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    eIF5AII
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be located in intracellular membrane-bounded organelle. Orthologous to human EIF5A2 (eukaryotic translation initiation factor 5A2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 187.3), Testes (RPKM 69.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif5a2 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (113656748..113674598)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (111728587..111746087)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (115336646..115354203)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene TRAF2 and NCK interacting kinase Neighboring gene uncharacterized LOC134485609 Neighboring gene solute carrier family 2 member 2 Neighboring gene ribosomal protein L22 like 1 Neighboring gene uncharacterized LOC134485729

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. Chen M, et al. BMC Cancer, 2011 May 26. PMID 21612665, Free PMC Article
    2. Identification and characterization of eukaryotic initiation factor 5A-2. Clement PM, et al. Eur J Biochem, 2003 Nov. PMID 14622290
    3. Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression. Jenkins ZA, et al. Genomics, 2001 Jan 1. PMID 11161802
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 5A-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100697.3 → NP_001094167.1  eukaryotic translation initiation factor 5A-2

      See identical proteins and their annotated locations for NP_001094167.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6IHJ3, G3V7J7
      Related
      ENSRNOP00000015779.5, ENSRNOT00000015779.9
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      113656748..113674598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232231.5 → XP_006232293.1  eukaryotic translation initiation factor 5A-2 isoform X1

      See identical proteins and their annotated locations for XP_006232293.1

      UniProtKB/TrEMBL
      A6IHJ3, G3V7J7
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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