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    Drosha drosha ribonuclease III [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310159, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Droshaprovided by RGD
    Official Full Name
    drosha ribonuclease IIIprovided by RGD
    Primary source
    RGD:1307626
    See related
    EnsemblRapid:ENSRNOG00000013451 AllianceGenome:RGD:1307626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rn3; Etohi2; Rnasen; RGD1307626
    Summary
    Predicted to enable several functions, including DEAD/H-box RNA helicase binding activity; R-SMAD binding activity; and lipopolysaccharide binding activity. Predicted to be involved in defense response to bacterium; miRNA processing; and positive regulation of gene expression. Predicted to act upstream of or within several processes, including miRNA metabolic process; regulation of miRNA metabolic process; and regulation of regulatory T cell differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of microprocessor complex. Predicted to be active in glutamatergic synapse; nucleus; and postsynaptic density. Orthologous to human DROSHA (drosha ribonuclease III). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 83.3), Kidney (RPKM 65.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Drosha in Genome Data Viewer
    Location:
    2q16
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (63591885..63703688)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (61864886..61976688)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (62887267..63000307)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909396 Neighboring gene similar to human chromosome 5 open reading frame 22 Neighboring gene uncharacterized LOC103695100 Neighboring gene cadherin 6 Neighboring gene 60S ribosomal protein L7a pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of putative rat ribonuclease III by differential display: a novel rat mRNA expressed in a circadian manner in the rat suprachiasmatic nucleus. Bhogal RK, et al. Brain Res Mol Brain Res, 2004 Nov 24. PMID 15530651
    2. The nuclear RNase III Drosha initiates microRNA processing. Lee Y, et al. Nature, 2003 Sep 25. PMID 14508493
    3. Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall. Torrent M, et al. FEBS J, 2010 Apr. PMID 20180804
    4. The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II. Pidíková P, et al. Gen Physiol Biophys, 2022 Sep. PMID 36222340
    5. The widespread regulation of microRNA biogenesis, function and decay. Krol J, et al. Nat Rev Genet, 2010 Sep. PMID 20661255

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.
      Title: The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DEAD/H-box RNA helicase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonuclease III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease III activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pre-miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in primary miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of microprocessor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of microprocessor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease 3
    Names
    drosha, ribonuclease type III
    ethanol induced 2
    ribonuclease III, nuclear
    ribonuclease type III, nuclear
    NP_001101125.2
    XP_006232112.2
    XP_038958133.1
    XP_038958134.1
    XP_038958135.1
    XP_063137814.1
    XP_063137815.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107655.2 → NP_001101125.2  ribonuclease 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5Y0A2, E9PTR3
      Related
      ENSRNOP00000076463.2, ENSRNOT00000098160.2
      Conserved Domains (3) summary
      PRK00102
      Location:1104 → 1332
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:958 → 1078
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      TIGR01622
      Location:212 → 274
      SF-CC1; splicing factor, CC1-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      63591885..63703688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232050.5 → XP_006232112.2  ribonuclease 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y0A2
      Conserved Domains (3) summary
      PRK00102
      Location:1096 → 1324
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:950 → 1070
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      TIGR01622
      Location:212 → 274
      SF-CC1; splicing factor, CC1-like family

    2. XM_063281745.1 → XP_063137815.1  ribonuclease 3 isoform X3

    3. XM_039102206.1 → XP_038958134.1  ribonuclease 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0A2, E9PTR3
      Related
      ENSRNOP00000050633.5, ENSRNOT00000048026.8
      Conserved Domains (3) summary
      PRK00102
      Location:1104 → 1332
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:958 → 1078
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      TIGR01622
      Location:212 → 274
      SF-CC1; splicing factor, CC1-like family

    4. XM_039102207.1 → XP_038958135.1  ribonuclease 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0A2, E9PTR3
      Conserved Domains (3) summary
      PRK00102
      Location:1104 → 1332
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:958 → 1078
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      TIGR01622
      Location:212 → 274
      SF-CC1; splicing factor, CC1-like family

    5. XM_063281744.1 → XP_063137814.1  ribonuclease 3 isoform X2

    6. XM_039102205.1 → XP_038958133.1  ribonuclease 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0A2, E9PTR3
      Conserved Domains (3) summary
      PRK00102
      Location:1104 → 1332
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:958 → 1078
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      TIGR01622
      Location:212 → 274
      SF-CC1; splicing factor, CC1-like family
    Nucleotide Protein Strain
    Heading Accession and Version

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