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    Rictor RPTOR independent companion of MTOR, complex 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310131, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rictorprovided by RGD
    Official Full Name
    RPTOR independent companion of MTOR, complex 2provided by RGD
    Primary source
    RGD:1307224
    See related
    EnsemblRapid:ENSRNOG00000011341 AllianceGenome:RGD:1307224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including protein kinase binding activity; protein serine/threonine kinase activator activity; and ribosome binding activity. Involved in positive regulation of endothelial cell proliferation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of phosphorylation. Predicted to be part of TORC2 complex. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 195.9), Adrenal (RPKM 180.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rictor in Genome Data Viewer
    Location:
    2q16
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (57539279..57631291)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (55811877..55903893)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (56013898..56105818)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100732 Neighboring gene uncharacterized LOC120100733 Neighboring gene complement C9 Neighboring gene FYN binding protein 1 Neighboring gene oncostatin M receptor Neighboring gene ribosomal protein L21, pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Rictor protein and Rictor-H. pylori interaction has impact on tumor progression and prognosis in patients with gastric cancer. Wang F, et al. Folia Histochem Cytobiol, 2020. PMID 32588907
    2. Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury. Chen N, et al. FASEB J, 2020 May. PMID 32232913
    3. Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network. Mok KW, et al. FASEB J, 2013 Mar. PMID 23288930, Free PMC Article
    4. MiR-424/503-mediated Rictor upregulation promotes tumor progression. Oneyama C, et al. PLoS One, 2013. PMID 24244675, Free PMC Article
    5. Molecular characterization of gallbladder cancer using somatic mutation profiling. Javle M, et al. Hum Pathol, 2014 Apr. PMID 24508317, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury.
      Title: Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury.
    2. upregulation of miR-424 inhibited Rictor through Akt signaling in renal tissue of diabetic nephropathy rats and high-glucose-treated human glomerular mesangial cells.
      Title: Upregulation of microRNA-424 relieved diabetic nephropathy by targeting Rictor through mTOR Complex2/Protein Kinase B signaling.
    3. Study examined mTOR variables, with attention to mTORC2 (Rictor), in Alzheimer's disease (AD) brain samples and in two mouse models, and made comparisons with results from cell- and in vitro-based experiments where Abeta is either expressed or peptide added. Authors conclude that striking a new balance by restoring mTORC2 abundance and/or inhibition of mTORC1 has therapeutic potential in AD.
      Title: mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.
    4. Study suggests that Rictor/mTORC2 signaling activation mediates TGFbeta1-induced fibroblast activation and contributes to the development of kidney fibrosis.
      Title: Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis.
    5. These data provide a novel mechanistic link of Nox4-dependent activation of mTORC2 via the energy sensor AMP-activated protein kinase to increased proliferation and survival of PAVSMCs in pulmonary artery hypertension.
      Title: Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension.
    6. Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction
      Title: Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TORC2 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryo development ending in birth or egg hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rapamycin-insensitive companion of mTOR

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433124.1 → NP_001420053.1  rapamycin-insensitive companion of mTOR isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    2. NM_001433125.1 → NP_001420054.1  rapamycin-insensitive companion of mTOR isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    3. NM_001433126.1 → NP_001420055.1  rapamycin-insensitive companion of mTOR isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      57539279..57631291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103527.1 → XP_038959455.1  rapamycin-insensitive companion of mTOR isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNG4, F1M4J0
      Related
      ENSRNOP00000079615.1, ENSRNOT00000109110.2
      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    2. XM_008760807.2 → XP_008759029.2  rapamycin-insensitive companion of mTOR isoform X3

      Related
      ENSRNOP00000030782.7, ENSRNOT00000029565.8
      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    3. XM_063282846.1 → XP_063138916.1  rapamycin-insensitive companion of mTOR isoform X2

    4. XM_039103528.1 → XP_038959456.1  rapamycin-insensitive companion of mTOR isoform X4

      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    Nucleotide Protein Strain
    Heading Accession and Version

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