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    Batf2 basic leucine zipper ATF-like transcription factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309178, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Batf2provided by RGD
    Official Full Name
    basic leucine zipper ATF-like transcription factor 2provided by RGD
    Primary source
    RGD:1311481
    See related
    EnsemblRapid:ENSRNOG00000021018 AllianceGenome:RGD:1311481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311481
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in defense response to protozoan; myeloid dendritic cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human BATF2 (basic leucine zipper ATF-like transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 17.3), Spleen (RPKM 13.1) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Batf2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212897076..212905740)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203467291..203479428)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221538006..221546650)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097396 Neighboring gene sorting nexin 15 Neighboring gene uncharacterized LOC134483958 Neighboring gene ADP-ribosylation factor like GTPase 2 Neighboring gene membrane anchored junction protein Neighboring gene protein phosphatase 2, regulatory subunit B', beta Neighboring gene glycoprotein hormone subunit alpha 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Compensatory dendritic cell development mediated by BATF-IRF interactions. Tussiwand R, et al. Nature, 2012 Oct 25. PMID 22992524, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to protozoan ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myeloid dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    basic leucine zipper transcriptional factor ATF-like 2
    Names
    basic leucine zipper transcription factor, ATF-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400817.1 → NP_001387746.1  basic leucine zipper transcriptional factor ATF-like 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HZE9, D3ZT85

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      212897076..212905740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094948.2 → XP_038950876.1  basic leucine zipper transcriptional factor ATF-like 2 isoform X2

      UniProtKB/TrEMBL
      A6HZF0
      Conserved Domains (2) summary
      cd14686
      Location:30 → 75
      bZIP; coiled coil [structural motif]
      cl21462
      Location:30 → 75
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    2. XM_039094962.2 → XP_038950890.1  basic leucine zipper transcriptional factor ATF-like 2 isoform X3

      UniProtKB/TrEMBL
      A6HZF0
      Related
      ENSRNOP00000028527.5, ENSRNOT00000028527.5
      Conserved Domains (2) summary
      cd14686
      Location:28 → 73
      bZIP; coiled coil [structural motif]
      cl21462
      Location:28 → 73
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    3. XM_039094945.2 → XP_038950873.1  basic leucine zipper transcriptional factor ATF-like 2 isoform X1

      UniProtKB/TrEMBL
      A6HZF0
      Conserved Domains (2) summary
      cd14686
      Location:30 → 76
      bZIP; coiled coil [structural motif]
      cl21462
      Location:30 → 76
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    4. XM_006230953.5 → XP_006231015.1  basic leucine zipper transcriptional factor ATF-like 2 isoform X1

      See identical proteins and their annotated locations for XP_006231015.1

      UniProtKB/TrEMBL
      A6HZF0
      Related
      ENSRNOP00000099307.1, ENSRNOT00000132463.1
      Conserved Domains (2) summary
      cd14686
      Location:30 → 76
      bZIP; coiled coil [structural motif]
      cl21462
      Location:30 → 76
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version

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