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    Pde8a phosphodiesterase 8A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308776, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pde8aprovided by RGD
    Official Full Name
    phosphodiesterase 8Aprovided by RGD
    Primary source
    RGD:735125
    See related
    EnsemblRapid:ENSRNOG00000019005 AllianceGenome:RGD:735125
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RNPDE8A
    Summary
    Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity; kinase binding activity; and protein kinase activator activity. Predicted to be involved in cAMP-mediated signaling; cellular response to epidermal growth factor stimulus; and positive regulation of ERK1 and ERK2 cascade. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Orthologous to human PDE8A (phosphodiesterase 8A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 166.4), Kidney (RPKM 127.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pde8a in Genome Data Viewer
    Location:
    1q31
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (144575203..144698216)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (135166143..135288986)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (143036083..143160395)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene alpha-kinase 3 Neighboring gene solute carrier family 28 member 1 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene ribosomal protein S17 Neighboring gene cytoplasmic polyadenylation element binding protein 1 Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 48, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Distribution of PDE8A in the nervous system of the Sprague-Dawley rat. Kruse LS, et al. J Chem Neuroanat, 2011 Nov. PMID 21821118
    2. Molecular comparison of rat cyclic nucleotide phosphodiesterase 8 family: unique expression of PDE8B in rat brain. Kobayashi T, et al. Gene, 2003 Nov 13. PMID 14597168
    3. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Soderling SH, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671792, Free PMC Article
    4. Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. Fisher DA, et al. Biochem Biophys Res Commun, 1998 May 29. PMID 9618252
    5. Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Brown KM, et al. Proc Natl Acad Sci U S A, 2013 Apr 16. PMID 23509299, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to epidermal growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
    Names
    cAMP-specific cyclic nucleotide phosphodiesterase PDE8
    NP_942062.1
    XP_006229500.1
    XP_038968970.2
    XP_038968971.2
    XP_038968972.2
    XP_038968973.1
    XP_063118773.1
    XP_063118774.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198767.1 → NP_942062.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

      See identical proteins and their annotated locations for NP_942062.1

      Status: PROVISIONAL

      Source sequence(s)
      AB092696
      UniProtKB/TrEMBL
      A6JCF1, Q76KC6
      Conserved Domains (4) summary
      cd00130
      Location:224 → 318
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:548 → 801
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08629
      Location:1 → 44
      PDE8; PDE8 phosphodiesterase
      pfam13426
      Location:220 → 318
      PAS_9; PAS domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      144575203..144698216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262703.1 → XP_063118773.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

    2. XM_006229438.5 → XP_006229500.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2

      See identical proteins and their annotated locations for XP_006229500.1

      UniProtKB/TrEMBL
      A6JCF1, Q76KC6
      Related
      ENSRNOP00000025797.3, ENSRNOT00000025797.5
      Conserved Domains (4) summary
      cd00130
      Location:224 → 318
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:548 → 801
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08629
      Location:1 → 44
      PDE8; PDE8 phosphodiesterase
      pfam13426
      Location:220 → 318
      PAS_9; PAS domain

    3. XM_063262704.1 → XP_063118774.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X4

    4. XM_039113045.2 → XP_038968973.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X6

      Conserved Domains (3) summary
      COG2202
      Location:118 → 318
      PAS; PAS domain [Signal transduction mechanisms]
      pfam08629
      Location:1 → 24
      PDE8; PDE8 phosphodiesterase
      pfam13426
      Location:220 → 318
      PAS_9; PAS domain

    5. XM_039113042.2 → XP_038968970.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3

    6. XM_039113043.2 → XP_038968971.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3

    7. XM_039113044.2 → XP_038968972.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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