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    Mctp2 multiple C2 and transmembrane domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308742, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Mctp2provided by RGD
    Official Full Name
    multiple C2 and transmembrane domain containing 2provided by RGD
    Primary source
    RGD:1562967
    See related
    EnsemblRapid:ENSRNOG00000009932 AllianceGenome:RGD:1562967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562967
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of neurotransmitter secretion. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in synaptic vesicle membrane. Predicted to be integral component of membrane. Orthologous to human MCTP2 (multiple C2 and transmembrane domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 62.4), Lung (RPKM 31.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mctp2 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (135179845..135412798, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (125769932..126002886, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (133324881..133559644, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099851 Neighboring gene uncharacterized LOC134485136 Neighboring gene uncharacterized LOC134485135 Neighboring gene uncharacterized LOC134485137 Neighboring gene spermatogenesis-associated protein 13-like Neighboring gene transfer RNA alanine (anticodon AGC) 79

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties. Shin OH, et al. J Biol Chem, 2005 Jan 14. PMID 15528213
    2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    multiple C2 and transmembrane domain-containing protein 2
    Names
    multiple C2 domains, transmembrane 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191625.2 → NP_001178554.1  multiple C2 and transmembrane domain-containing protein 2

      See identical proteins and their annotated locations for NP_001178554.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A096MKH3, D4A733
      Related
      ENSRNOP00000068515.2, ENSRNOT00000077049.3
      Conserved Domains (4) summary
      cd04042
      Location:189 → 308
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:351 → 463
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:503 → 621
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:765 → 818
      PRT_C; Plant phosphoribosyltransferase C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      135179845..135412798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589163.3 → XP_017444652.1  multiple C2 and transmembrane domain-containing protein 2 isoform X2

    2. XM_008759526.3 → XP_008757748.2  multiple C2 and transmembrane domain-containing protein 2 isoform X3

    3. XM_039112926.2 → XP_038968854.1  multiple C2 and transmembrane domain-containing protein 2 isoform X4

      Conserved Domains (3) summary
      cd08377
      Location:77 → 195
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:339 → 392
      PRT_C; Plant phosphoribosyltransferase C-terminal
      cl14603
      Location:3 → 37
      C2; C2 domain

    4. XM_017589162.3 → XP_017444651.2  multiple C2 and transmembrane domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      D4A733
      Conserved Domains (3) summary
      cd04042
      Location:189 → 308
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:351 → 463
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:503 → 621
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

    RNA

    1. XR_005505581.2 RNA Sequence

    2. XR_005505582.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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