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    Dyrk1b dual specificity tyrosine phosphorylation regulated kinase 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308468, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dyrk1bprovided by RGD
    Official Full Name
    dual specificity tyrosine phosphorylation regulated kinase 1Bprovided by RGD
    Primary source
    RGD:1307223
    See related
    EnsemblRapid:ENSRNOG00000019254 AllianceGenome:RGD:1307223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Predicted to be involved in adipose tissue development; positive regulation of DNA-templated transcription; and protein phosphorylation. Predicted to act upstream of or within myoblast fusion. Predicted to be located in chromosome and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 3. Orthologous to human DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 280.0), Testes (RPKM 192.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dyrk1b in Genome Data Viewer
    Location:
    1q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (92606743..92624089)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (83479168..83497011)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (85112819..85120840)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Fc fragment of IgG binding protein-like 1 Neighboring gene fibrillarin Neighboring gene EP300 interacting inhibitor of differentiation 2 Neighboring gene EP300 interacting inhibitor of differentiation 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A form of the metabolic syndrome associated with mutations in DYRK1B. Keramati AR, et al. N Engl J Med, 2014 May 15. PMID 24827035, Free PMC Article
    2. Mirk/dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation. Deng X, et al. J Biol Chem, 2003 Oct 17. PMID 12902328
    3. Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. Lim S, et al. J Biol Chem, 2002 Jul 12. PMID 11980910
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myoblast fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 1B
    Names
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
    NP_001100966.1
    NP_001402788.1
    NP_001402789.1
    XP_006228684.1
    XP_006228685.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107496.2 → NP_001100966.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform 3

      See identical proteins and their annotated locations for NP_001100966.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J9H2, D4ACC4
      Conserved Domains (2) summary
      smart00220
      Location:111 → 391
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14226
      Location:97 → 396
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    2. NM_001415859.1 → NP_001402788.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2KAP6
      Related
      ENSRNOP00000075476.2, ENSRNOT00000087157.3

    3. NM_001415860.1 → NP_001402789.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZP97, A6J9H1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      92606743..92624089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228622.5 → XP_006228684.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

      UniProtKB/TrEMBL
      D4ACC4
      Related
      ENSRNOP00000026107.7, ENSRNOT00000026107.8
      Conserved Domains (2) summary
      smart00220
      Location:171 → 463
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14226
      Location:157 → 468
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    2. XM_006228623.5 → XP_006228685.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

      UniProtKB/TrEMBL
      D4ACC4
      Conserved Domains (2) summary
      smart00220
      Location:171 → 451
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14226
      Location:157 → 456
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    Nucleotide Protein Strain
    Heading Accession and Version

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