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    Ccr6 C-C motif chemokine receptor 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308163, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Ccr6provided by RGD
    Official Full Name
    C-C motif chemokine receptor 6provided by RGD
    Primary source
    RGD:1308562
    See related
    EnsemblRapid:ENSRNOG00000012964 AllianceGenome:RGD:1308562
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Involved in positive regulation of cytosolic calcium ion concentration; positive regulation of dendritic cell chemotaxis; and positive regulation of epithelial cell migration. Predicted to be located in cell surface; sperm flagellum; and sperm plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of membranoproliferative glomerulonephritis and transient cerebral ischemia. Orthologous to human CCR6 (C-C motif chemokine receptor 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 80.7), Thymus (RPKM 21.0) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccr6 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (55022037..55055857, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (52474477..52508301, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (53063380..53087519, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene SFT2 domain containing 1 Neighboring gene mitochondrial pyruvate carrier 1 Neighboring gene uncharacterized LOC134482722 Neighboring gene centrosomal protein 43 Neighboring gene uncharacterized LOC134484997 Neighboring gene uncharacterized LOC134484998 Neighboring gene ribonuclease T2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The role of CC chemokine receptor 6 in host defense in a model of invasive pulmonary aspergillosis. Phadke AP, et al. Am J Respir Crit Care Med, 2007 Jun 1. PMID 17379855, Free PMC Article
    2. In situ demonstration of dendritic cell migration from rat intestine to mesenteric lymph nodes: relationships to maturation and role of chemokines. Kobayashi H, et al. J Leukoc Biol, 2004 Mar. PMID 14673014
    3. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Reboldi A, et al. Science, 2016 May 13. PMID 27174992, Free PMC Article
    4. CCR6 selectively promotes monocyte mediated inflammation and atherogenesis in mice. Manthey HD, et al. Thromb Haemost, 2013 Dec. PMID 24114205
    5. Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms. Villa L, et al. J Pathol, 2013 Apr. PMID 23192593

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggest a potential mechanism for the recruitment of IL-17-producing cells to degenerated intervertebral discs via a CCL20/CCR6 axis in vivo.
      Title: Production of CCL20 on nucleus pulposus cells recruits IL-17-producing cells to degenerated IVD tissues in rat models.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108876

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DN2 thymocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DN3 thymocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isotype switching to IgA isotypes ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte migration involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lymphocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dendritic cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of dendritic cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of flagellated sperm motility involved in capacitation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of T-helper 17 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thymocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thymocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    C-C chemokine receptor type 6
    Names
    CC chemokine receptor 6
    chemokine (C-C motif) receptor 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013145.1 → NP_001013163.1  C-C chemokine receptor type 6

      See identical proteins and their annotated locations for NP_001013163.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091197
      UniProtKB/TrEMBL
      A0A8I5ZP26, A6KK39, Q5BK58
      Related
      ENSRNOP00000017302.3, ENSRNOT00000017302.8
      Conserved Domains (1) summary
      cd15172
      Location:38 → 318
      7tmA_CCR6; CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      55022037..55055857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110679.2 → XP_038966607.1  C-C chemokine receptor type 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZP26, A6KK39, Q5BK58
      Conserved Domains (1) summary
      cd15172
      Location:38 → 318
      7tmA_CCR6; CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_039110677.2 → XP_038966605.1  C-C chemokine receptor type 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZP26, A6KK39, Q5BK58
      Conserved Domains (1) summary
      cd15172
      Location:38 → 318
      7tmA_CCR6; CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_008758755.4 → XP_008756977.1  C-C chemokine receptor type 6 isoform X1

      See identical proteins and their annotated locations for XP_008756977.1

      UniProtKB/TrEMBL
      A0A8I5ZP26, A6KK39, Q5BK58
      Related
      ENSRNOP00000078735.1, ENSRNOT00000114764.2
      Conserved Domains (1) summary
      cd15172
      Location:38 → 318
      7tmA_CCR6; CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_008758756.4 → XP_008756978.1  C-C chemokine receptor type 6 isoform X1

      See identical proteins and their annotated locations for XP_008756978.1

      UniProtKB/TrEMBL
      A0A8I5ZP26, A6KK39, Q5BK58
      Conserved Domains (1) summary
      cd15172
      Location:38 → 318
      7tmA_CCR6; CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version

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