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    Celf4 CUGBP, Elav-like family member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307540, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Celf4provided by RGD
    Official Full Name
    CUGBP, Elav-like family member 4provided by RGD
    Primary source
    RGD:1307630
    See related
    EnsemblRapid:ENSRNOG00000014503 AllianceGenome:RGD:1307630
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Brunol4
    Summary
    Predicted to enable mRNA binding activity and pre-mRNA binding activity. Predicted to be involved in mRNA splice site selection; positive regulation of mRNA splicing, via spliceosome; and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within several processes, including alternative mRNA splicing, via spliceosome; negative regulation of excitatory postsynaptic potential; and negative regulation of mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CELF4 (CUGBP Elav-like family member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 286.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Celf4 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (17061284..17339747, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (16786578..17065045, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (17689090..18079835, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene formin homology 2 domain containing 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene tubulin polyglutamylase complex subunit 2 Neighboring gene KIAA1328 homolog Neighboring gene uncharacterized LOC120098197 Neighboring gene uncharacterized LOC103694180

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Etiology of a genetically complex seizure disorder in Celf4 mutant mice. Wagnon JL, et al. Genes Brain Behav, 2011 Oct. PMID 21745337, Free PMC Article
    2. MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1. Kino Y, et al. Nucleic Acids Res, 2009 Oct. PMID 19720736, Free PMC Article
    3. The expression analysis of Sfrs10 and Celf4 during mouse retinal development. Karunakaran DK, et al. Gene Expr Patterns, 2013 Dec. PMID 23932931, Free PMC Article
    4. The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Ladd AN, et al. Mol Cell Biol, 2001 Feb. PMID 11158314, Free PMC Article
    5. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. Wang J, et al. J Neurochem, 2004 Mar. PMID 15009664

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA splice site recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CUGBP Elav-like family member 4
    Names
    CUG-BP- and ETR-3-like factor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401250.2 → NP_001388179.1  CUGBP Elav-like family member 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I5ZKE7
      Related
      ENSRNOP00000077924.1, ENSRNOT00000107952.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      17061284..17339747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096895.2 → XP_038952823.1  CUGBP Elav-like family member 4 isoform X15

      Conserved Domains (3) summary
      cd12632
      Location:49 → 135
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:141 → 221
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:407 → 435
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_039096893.2 → XP_038952821.1  CUGBP Elav-like family member 4 isoform X13

      Conserved Domains (3) summary
      cd12632
      Location:49 → 135
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:150 → 230
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:416 → 444
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_063277417.1 → XP_063133487.1  CUGBP Elav-like family member 4 isoform X37

    4. XM_039096896.2 → XP_038952824.1  CUGBP Elav-like family member 4 isoform X14

      Conserved Domains (3) summary
      cd12632
      Location:49 → 135
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:140 → 220
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:406 → 434
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_039096913.2 → XP_038952841.1  CUGBP Elav-like family member 4 isoform X9

      Conserved Domains (3) summary
      cd12632
      Location:49 → 135
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:140 → 220
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:406 → 454
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_039096889.2 → XP_038952817.1  CUGBP Elav-like family member 4 isoform X4

      Conserved Domains (3) summary
      cd12632
      Location:49 → 135
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:150 → 230
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:416 → 464
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_039096892.2 → XP_038952820.1  CUGBP Elav-like family member 4 isoform X11

      Conserved Domains (4) summary
      TIGR01628
      Location:56 → 378
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12632
      Location:49 → 135
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:151 → 231
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:417 → 445
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. XM_039096888.2 → XP_038952816.1  CUGBP Elav-like family member 4 isoform X3

      Conserved Domains (4) summary
      TIGR01628
      Location:56 → 378
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12632
      Location:49 → 135
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:151 → 231
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:417 → 465
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. XM_063277416.1 → XP_063133486.1  CUGBP Elav-like family member 4 isoform X36

    10. XM_063277391.1 → XP_063133461.1  CUGBP Elav-like family member 4 isoform X6

    11. XM_063277392.1 → XP_063133462.1  CUGBP Elav-like family member 4 isoform X10

    12. XM_063277393.1 → XP_063133463.1  CUGBP Elav-like family member 4 isoform X16

    13. XM_039096886.2 → XP_038952814.1  CUGBP Elav-like family member 4 isoform X1

      Conserved Domains (4) summary
      TIGR01628
      Location:56 → 378
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12632
      Location:49 → 135
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:151 → 231
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:417 → 465
      RRM_SF; RNA recognition motif (RRM) superfamily

    14. XM_063277390.1 → XP_063133460.1  CUGBP Elav-like family member 4 isoform X5

    15. XM_063277389.1 → XP_063133459.1  CUGBP Elav-like family member 4 isoform X2

    16. XM_039096890.2 → XP_038952818.1  CUGBP Elav-like family member 4 isoform X7

      Conserved Domains (4) summary
      TIGR01628
      Location:56 → 378
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12632
      Location:49 → 135
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:151 → 231
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:417 → 445
      RRM_SF; RNA recognition motif (RRM) superfamily

    17. XM_039096894.2 → XP_038952822.1  CUGBP Elav-like family member 4 isoform X12

      Conserved Domains (3) summary
      cd12632
      Location:49 → 135
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:140 → 220
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:406 → 434
      RRM_SF; RNA recognition motif (RRM) superfamily

    18. XM_039096891.2 → XP_038952819.1  CUGBP Elav-like family member 4 isoform X8

      Conserved Domains (3) summary
      cd12632
      Location:49 → 135
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:150 → 230
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:416 → 444
      RRM_SF; RNA recognition motif (RRM) superfamily

    19. XM_063277413.1 → XP_063133483.1  CUGBP Elav-like family member 4 isoform X33

    20. XM_063277414.1 → XP_063133484.1  CUGBP Elav-like family member 4 isoform X34

    21. XM_063277412.1 → XP_063133482.1  CUGBP Elav-like family member 4 isoform X33

    22. XM_063277405.1 → XP_063133475.1  CUGBP Elav-like family member 4 isoform X27

    23. XM_063277411.1 → XP_063133481.1  CUGBP Elav-like family member 4 isoform X32

    24. XM_063277404.1 → XP_063133474.1  CUGBP Elav-like family member 4 isoform X26

    25. XM_063277399.1 → XP_063133469.1  CUGBP Elav-like family member 4 isoform X22

    26. XM_063277410.1 → XP_063133480.1  CUGBP Elav-like family member 4 isoform X31

    27. XM_063277403.1 → XP_063133473.1  CUGBP Elav-like family member 4 isoform X25

    28. XM_063277398.1 → XP_063133468.1  CUGBP Elav-like family member 4 isoform X21

    29. XM_063277409.1 → XP_063133479.1  CUGBP Elav-like family member 4 isoform X30

    30. XM_063277402.1 → XP_063133472.1  CUGBP Elav-like family member 4 isoform X24

    31. XM_063277397.1 → XP_063133467.1  CUGBP Elav-like family member 4 isoform X20

    32. XM_063277395.1 → XP_063133465.1  CUGBP Elav-like family member 4 isoform X18

    33. XM_063277415.1 → XP_063133485.1  CUGBP Elav-like family member 4 isoform X35

    34. XM_063277408.1 → XP_063133478.1  CUGBP Elav-like family member 4 isoform X29

    35. XM_063277406.1 → XP_063133476.1  CUGBP Elav-like family member 4 isoform X28

    36. XM_063277400.1 → XP_063133470.1  CUGBP Elav-like family member 4 isoform X23

      UniProtKB/TrEMBL
      A0A8I5ZKE7

    37. XM_063277396.1 → XP_063133466.1  CUGBP Elav-like family member 4 isoform X19

    38. XM_063277394.1 → XP_063133464.1  CUGBP Elav-like family member 4 isoform X17

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107400.1: Suppressed sequence

      Description
      NM_001107400.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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