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    rrm1 ribonucleotide reductase M1 polypeptide [ Danio rerio (zebrafish) ]

    Gene ID: 30740, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rrm1provided by ZNC
    Official Full Name
    ribonucleotide reductase M1 polypeptideprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-247
    See related
    Ensembl:ENSDARG00000014017 AllianceGenome:ZFIN:ZDB-GENE-990415-247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    r1; cb396; cb838; sb:cb548; CHUNP6866; wu:fb39b07; wu:fi14b02; wu:fk95f07
    Summary
    Predicted to enable ATP binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Predicted to be involved in deoxyribonucleotide biosynthetic process. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including immature eye; nervous system; neural tube; presumptive telencephalon; and tail bud. Human ortholog(s) of this gene implicated in chronic progressive external ophthalmoplegia. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rrm1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (30772188..30787414, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (30735190..30750719, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel subfamily C member 2b Neighboring gene uncharacterized LOC137488830 Neighboring gene solute carrier family 6 member 7 Neighboring gene stromal interaction molecule 1b Neighboring gene uncharacterized LOC101886778

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia. Danilova N, et al. Dis Model Mech, 2014 Jul. PMID 24812435, Free PMC Article
    2. Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients. Mans DA, et al. J Pathol, 2013 Sep. PMID 23744542
    3. GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFβ signaling. Willaert A, et al. Hum Mol Genet, 2012 Mar 15. PMID 22116938, Free PMC Article
    4. Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. Kuil LE, et al. Elife, 2020 May 5. PMID 32367800, Free PMC Article
    5. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in deoxyribonucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within deoxyribonucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in deoxyribonucleotide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoside-diphosphate reductase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribonucleoside-diphosphate reductase large subunit
    Names
    ribonucleoside-diphosphate reductase subunit M1
    ribonucleotide reductase large subunit
    ribonucleotide reductase protein r1 class I
    NP_571530.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131455.2 → NP_571530.2  ribonucleoside-diphosphate reductase large subunit

      Status: VALIDATED

      Source sequence(s)
      BX511168, CT631855, CT676109, EB847840, EH588550
      UniProtKB/Swiss-Prot
      P79732
      UniProtKB/TrEMBL
      A0A8M1PC36, F1R2K9
      Related
      ENSDARP00000010800.7, ENSDART00000012091.9
      Conserved Domains (3) summary
      cd01679
      Location:167 → 741
      RNR_I; Class I ribonucleotide reductase
      PLN02437
      Location:1 → 794
      PLN02437; ribonucleoside--diphosphate reductase large subunit
      pfam03477
      Location:1 → 89
      ATP-cone; ATP cone domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      30772188..30787414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79732.1 GenPept UniProtKB/Swiss-Prot:P79732

    Gene LinkOut

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