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    Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307248, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Pstpip2provided by RGD
    Official Full Name
    proline-serine-threonine phosphatase-interacting protein 2provided by RGD
    Primary source
    RGD:1563090
    See related
    EnsemblRapid:ENSRNOG00000016987 AllianceGenome:RGD:1563090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563090
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament polymerization. Predicted to be located in cytoskeleton; cytosol; and membrane. Predicted to be active in actin filament; cytoplasm; and plasma membrane. Orthologous to human PSTPIP2 (proline-serine-threonine phosphatase interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 53.0), Spleen (RPKM 35.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pstpip2 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (73585729..73671868)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (71310387..71396752)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (74173809..74291188)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene HAUS augmin-like complex, subunit 1 Neighboring gene ATP synthase F1 subunit alpha Neighboring gene ectopic P-granules 5 autophagy tethering factor Neighboring gene sialic acid binding Ig-like lectin 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel macrophage actin-associated protein (MAYP) is tyrosine-phosphorylated following colony stimulating factor-1 stimulation. Yeung YG, et al. J Biol Chem, 1998 Nov 13. PMID 9804836
    2. PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. Wu Y, et al. J Biol Chem, 1998 Nov 13. PMID 9804817
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    proline-serine-threonine phosphatase-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271281.1 → NP_001258210.1  proline-serine-threonine phosphatase-interacting protein 2

      See identical proteins and their annotated locations for NP_001258210.1

      Status: VALIDATED

      Source sequence(s)
      CB770049, CK364772, FQ120558, JAXUCZ010000018
      UniProtKB/TrEMBL
      A6KMX0, D3ZA66
      Related
      ENSRNOP00000109704.1, ENSRNOT00000138357.1
      Conserved Domains (1) summary
      cd07672
      Location:15 → 254
      F-BAR_PSTPIP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      73585729..73671868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096774.2 → XP_038952702.1  proline-serine-threonine phosphatase-interacting protein 2 isoform X1

      UniProtKB/TrEMBL
      D3ZA66
      Related
      ENSRNOP00000107719.1, ENSRNOT00000163964.1
      Conserved Domains (1) summary
      cl12013
      Location:15 → 228
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_005496027.2 RNA Sequence

      Related
      ENSRNOT00000022833.10
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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