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    Btn1a1 butyrophilin, subfamily 1, member A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306956, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Btn1a1provided by RGD
    Official Full Name
    butyrophilin, subfamily 1, member A1provided by RGD
    Primary source
    RGD:1306984
    See related
    EnsemblRapid:ENSRNOG00000017514 AllianceGenome:RGD:1306984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway; negative regulation of activated T cell proliferation; and negative regulation of cytokine production. Predicted to be active in external side of plasma membrane. Orthologous to human BTN1A1 (butyrophilin subfamily 1 member A1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 3.5), Spleen (RPKM 3.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Btn1a1 in Genome Data Viewer
    Location:
    17p11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (42080217..42092286)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (41653499..41664246)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (43899155..43909042)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482713 Neighboring gene transfer RNA tryptophan (anticodon CCA) 8 Neighboring gene butyrophilin, subfamily 2, member A2 Neighboring gene transfer RNA glutamic acid (anticodon UUC) 10 Neighboring gene transfer RNA leucine (anticodon CAG) 9 Neighboring gene transfer RNA threonine (anticodon AGU) 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation. Smith IA, et al. J Immunol, 2010 Apr 1. PMID 20208008
    2. Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Palmer DJ, et al. Proteomics, 2006 Apr. PMID 16502470
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    butyrophilin subfamily 1 member A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170337.3 → NP_001163808.1  butyrophilin subfamily 1 member A1 precursor

      See identical proteins and their annotated locations for NP_001163808.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      F1LRV5, Q6EHI2
      Related
      ENSRNOP00000023622.3, ENSRNOT00000023622.7
      Conserved Domains (3) summary
      cd15819
      Location:304 → 474
      SPRY_PRY_BTN1_2; butyrophilin subfamily member A1 and A2 (BTN1A and BTN2A)
      cd00096
      Location:31 → 35
      Ig; Ig strand A [structural motif]
      cl11960
      Location:30 → 143
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      42080217..42092286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276434.1 → XP_063132504.1  butyrophilin subfamily 1 member A1 isoform X1

      UniProtKB/TrEMBL
      F1LRV5

    2. XM_063276438.1 → XP_063132508.1  butyrophilin subfamily 1 member A1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGT1

    3. XM_063276437.1 → XP_063132507.1  butyrophilin subfamily 1 member A1 isoform X2

    4. XM_063276436.1 → XP_063132506.1  butyrophilin subfamily 1 member A1 isoform X1

      UniProtKB/TrEMBL
      F1LRV5

    5. XM_063276435.1 → XP_063132505.1  butyrophilin subfamily 1 member A1 isoform X1

      UniProtKB/TrEMBL
      F1LRV5

    6. XM_063276439.1 → XP_063132509.1  butyrophilin subfamily 1 member A1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGT1
      Related
      ENSRNOP00000093963.1, ENSRNOT00000105103.2
    Nucleotide Protein Strain
    Heading Accession and Version

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