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    Gcnt2 glucosaminyl (N-acetyl) transferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306860, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gcnt2provided by RGD
    Official Full Name
    glucosaminyl (N-acetyl) transferase 2provided by RGD
    Primary source
    RGD:1303198
    See related
    EnsemblRapid:ENSRNOG00000023778 AllianceGenome:RGD:1303198
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ignt; Gcnt6
    Summary
    Predicted to enable N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity. Predicted to be involved in several processes, including maintenance of lens transparency; positive regulation of intracellular signal transduction; and transforming growth factor beta receptor signaling pathway. Predicted to be located in Golgi apparatus. Human ortholog(s) of this gene implicated in cataract and cataract 13 with adult i phenotype. Orthologous to human GCNT2 (glucosaminyl (N-acetyl) transferase 2 (I blood group)). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Lung (RPKM 53.1), Kidney (RPKM 49.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gcnt2 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (24002592..24107339, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (23796859..23901625, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (21634546..21677477, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482840 Neighboring gene PAK1 interacting protein 1 Neighboring gene similar to human chromosome 6 open reading frame 52 Neighboring gene uncharacterized LOC103694058 Neighboring gene uncharacterized LOC120097872 Neighboring gene uncharacterized LOC120097871 Neighboring gene ribosomal protein L9-like Neighboring gene glucosaminyl (N-acetyl) transferase 2, pseudogene 1 Neighboring gene ribosomal protein L29, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A nonsense mutation in the glucosaminyl (N-acetyl) transferase 2 gene (GCNT2): association with autosomal recessive congenital cataracts. Pras E, et al. Invest Ophthalmol Vis Sci, 2004 Jun. PMID 15161861
    2. The molecular genetics of the mouse I beta-1,6-N-acetylglucosaminyltransferase locus. Twu YC, et al. Biochem Biophys Res Commun, 2003 Apr 11. PMID 12670491
    3. The molecular genetics of the human I locus and molecular background explain the partial association of the adult i phenotype with congenital cataracts. Yu LC, et al. Blood, 2003 Mar 15. PMID 12424189
    4. Engagement of I-branching {beta}-1, 6-N-acetylglucosaminyltransferase 2 in breast cancer metastasis and TGF-{beta} signaling. Zhang H, et al. Cancer Res, 2011 Jul 15. PMID 21750175, Free PMC Article
    5. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, et al. Genome Res, 2004 Jan. PMID 14672974, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in maintenance of lens transparency ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
    Names
    I-branching beta-1,6-acetylglucosaminyltransferase
    N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase-like
    glucosaminyl (N-acetyl) transferase 2 (I blood group)
    glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
    glucosaminyl (N-acetyl) transferase 6
    NP_001001511.1
    NP_001387780.1
    XP_038951614.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001511.4 → NP_001001511.1  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform 2

      See identical proteins and their annotated locations for NP_001001511.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      Q6T5D9
      Related
      ENSRNOP00000029151.3, ENSRNOT00000035448.6
      Conserved Domains (1) summary
      pfam02485
      Location:95 → 356
      Branch; Core-2/I-Branching enzyme

    2. NM_001400851.1 → NP_001387780.1  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A0G2KAF0, Q6T5E0
      Related
      ENSRNOP00000075374.1, ENSRNOT00000078010.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      24002592..24107339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095686.2 → XP_038951614.1  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform X1

      UniProtKB/TrEMBL
      F7FDB0, Q6T5E1
      Related
      ENSRNOP00000057083.3, ENSRNOT00000060335.5
      Conserved Domains (1) summary
      pfam02485
      Location:95 → 356
      Branch; Core-2/I-Branching enzyme

    RNA

    1. XR_005495276.2 RNA Sequence

    2. XR_005495275.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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