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    Mylip myosin regulatory light chain interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306825, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mylipprovided by RGD
    Official Full Name
    myosin regulatory light chain interacting proteinprovided by RGD
    Primary source
    RGD:1305761
    See related
    EnsemblRapid:ENSRNOG00000017579 AllianceGenome:RGD:1305761
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MIR
    Summary
    Predicted to enable cytoskeletal protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cholesterol homeostasis; negative regulation of low-density lipoprotein particle clearance; and regulation of protein catabolic process. Predicted to be located in cytoplasm; cytoskeleton; and plasma membrane. Orthologous to human MYLIP (myosin regulatory light chain interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 172.9), Thymus (RPKM 158.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mylip in Genome Data Viewer
    Location:
    17p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (19492826..19514490, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (19286649..19308295, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (19682040..19703681, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene guanosine monophosphate reductase Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102549787 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482828

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of PCSK9 and IDOL in the pathogenesis of acquired LDL receptor deficiency and hypercholesterolemia in nephrotic syndrome. Liu S, et al. Nephrol Dial Transplant, 2014 Mar. PMID 24166456
    2. Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of the E3 ligase Mylip/Idol. Do HT, et al. J Biol Chem, 2013 Oct 11. PMID 23990472, Free PMC Article
    3. Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR. Bornhauser BC, et al. FEBS Lett, 2003 Oct 9. PMID 14550572
    4. MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. Olsson PA, et al. J Biol Chem, 1999 Dec 17. PMID 10593918
    5. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Zelcer N, et al. Science, 2009 Jul 3. PMID 19520913, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LDLR deficiency, hypercholesterolemia and elevated plasma LDL in NS are associated with upregulation of PCSK9 and IDOL.
      Title: Role of PCSK9 and IDOL in the pathogenesis of acquired LDL receptor deficiency and hypercholesterolemia in nephrotic syndrome.
    2. Data indicate that down-regulation of Mylip/Idol using shRNAs abrogated the decrease in VLDLRs induced by Reelin.
      Title: Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of the E3 ligase Mylip/Idol.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of low-density lipoprotein particle receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MYLIP
    Names
    RING-type E3 ubiquitin transferase MYLIP
    idol
    inducible degrader of the LDL-receptor
    NP_001100814.2
    XP_063132444.1
    XP_063132445.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107344.2 → NP_001100814.2  E3 ubiquitin-protein ligase MYLIP

      See identical proteins and their annotated locations for NP_001100814.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      D3ZDI6
      Related
      ENSRNOP00000024021.4, ENSRNOT00000024021.8
      Conserved Domains (4) summary
      smart00295
      Location:5 → 190
      B41; Band 4.1 homologues
      cd13195
      Location:185 → 295
      FERM_C_MYLIP_IDOL; FERM domain C-lobe of E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also called inducible degrader of the LDL receptor, IDOL)
      cd16523
      Location:386 → 423
      RING-HC_MYLIP; RING finger, HC subclass, found in myosin regulatory light chain interacting protein (MYLIP) and similar proteins
      cd17104
      Location:1 → 81
      FERM_F1_MYLIP; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in E3 ubiquitin-protein ligase MYLIP and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      19492826..19514490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276374.1 → XP_063132444.1  E3 ubiquitin-protein ligase MYLIP isoform X1

    2. XM_063276375.1 → XP_063132445.1  E3 ubiquitin-protein ligase MYLIP isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZDI6.1 GenPept UniProtKB/Swiss-Prot:D3ZDI6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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