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    Nek3 NIMA-related kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306576, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nek3provided by RGD
    Official Full Name
    NIMA-related kinase 3provided by RGD
    Primary source
    RGD:1307419
    See related
    EnsemblRapid:ENSRNOG00000012757 AllianceGenome:RGD:1307419
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including neuron projection morphogenesis; protein phosphorylation; and regulation of tubulin deacetylation. Orthologous to human NEK3 (NIMA related kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 41.4), Lung (RPKM 19.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nek3 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (76569465..76594921)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69867020..69892477)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74781371..74806567)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 36 homolog Neighboring gene cytoskeleton associated protein 2 Neighboring gene NIMA-related kinase 5 Neighboring gene ALG11, alpha-1,2-mannosyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. Chang J, et al. J Cell Sci, 2009 Jul 1. PMID 19509051, Free PMC Article
    2. Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. Miller SL, et al. Mol Endocrinol, 2005 Apr. PMID 15618286

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek3
    Names
    NIMA (never in mitosis gene a)-related expressed kinase 3
    NIMA (never in mitosis gene a)-related kinase 3
    NP_001414097.1
    XP_006253421.1
    XP_006253422.1
    XP_006253423.1
    XP_006253424.1
    XP_006253425.1
    XP_038951161.1
    XP_038951162.1
    XP_063131527.1
    XP_063131528.1
    XP_063131529.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427168.1 → NP_001414097.1  serine/threonine-protein kinase Nek3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IW84

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      76569465..76594921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095233.2 → XP_038951161.1  serine/threonine-protein kinase Nek3 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:3 → 254
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039095234.2 → XP_038951162.1  serine/threonine-protein kinase Nek3 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:3 → 254
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006253359.5 → XP_006253421.1  serine/threonine-protein kinase Nek3 isoform X1

      See identical proteins and their annotated locations for XP_006253421.1

      UniProtKB/TrEMBL
      A0A0G2K6R1, D3ZCU1
      Related
      ENSRNOP00000017107.7, ENSRNOT00000017106.8
      Conserved Domains (2) summary
      smart00220
      Location:4 → 252
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:3 → 257
      PKc_like; Protein Kinases, catalytic domain

    4. XM_006253361.5 → XP_006253423.1  serine/threonine-protein kinase Nek3 isoform X2

      See identical proteins and their annotated locations for XP_006253423.1

      UniProtKB/TrEMBL
      A0A0G2K6R1
      Related
      ENSRNOP00000073909.2, ENSRNOT00000090646.3
      Conserved Domains (2) summary
      smart00220
      Location:4 → 252
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:3 → 257
      PKc_like; Protein Kinases, catalytic domain

    5. XM_006253362.5 → XP_006253424.1  serine/threonine-protein kinase Nek3 isoform X3

      See identical proteins and their annotated locations for XP_006253424.1

      UniProtKB/TrEMBL
      A0A0G2K6R1
      Conserved Domains (2) summary
      smart00220
      Location:4 → 252
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:3 → 257
      PKc_like; Protein Kinases, catalytic domain

    6. XM_006253360.5 → XP_006253422.1  serine/threonine-protein kinase Nek3 isoform X1

      See identical proteins and their annotated locations for XP_006253422.1

      UniProtKB/TrEMBL
      A0A0G2K6R1, D3ZCU1
      Conserved Domains (2) summary
      smart00220
      Location:4 → 252
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:3 → 257
      PKc_like; Protein Kinases, catalytic domain

    7. XM_063275457.1 → XP_063131527.1  serine/threonine-protein kinase Nek3 isoform X2

    8. XM_063275458.1 → XP_063131528.1  serine/threonine-protein kinase Nek3 isoform X4

      UniProtKB/TrEMBL
      A6IW84

    9. XM_063275459.1 → XP_063131529.1  serine/threonine-protein kinase Nek3 isoform X5

    10. XM_006253363.3 → XP_006253425.1  serine/threonine-protein kinase Nek3 isoform X5

      See identical proteins and their annotated locations for XP_006253425.1

      Conserved Domains (2) summary
      smart00220
      Location:1 → 174
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1 → 179
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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