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    Htra4 HtrA serine peptidase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306564, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Htra4provided by RGD
    Official Full Name
    HtrA serine peptidase 4provided by RGD
    Primary source
    RGD:1306242
    See related
    EnsemblRapid:ENSRNOG00000061160 AllianceGenome:RGD:1306242
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306242
    Summary
    Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Predicted to be involved in positive regulation of apoptotic process; programmed cell death; and proteolysis. Predicted to be located in extracellular region. Orthologous to human HTRA4 (HtrA serine peptidase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 95.2), Lung (RPKM 87.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Htra4 in Genome Data Viewer
    Location:
    16q12.4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73704255..73717722)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (67001605..67015074)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71784819..71802765)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene transforming, acidic coiled-coil containing protein 1 Neighboring gene pleckstrin homology domain containing A2 Neighboring gene uncharacterized LOC134482519 Neighboring gene TM2 domain containing 2 Neighboring gene ADAM metallopeptidase domain 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A pathway sensor for genome-wide screens of intracellular proteolytic cleavage. Ketteler R, et al. Genome Biol, 2008 Apr 3. PMID 18387192, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in programmed cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease HTR4
    Names
    high-temperature requirement factor A4
    probable serine protease HTRA4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107321.3 → NP_001100791.1  serine protease HTR4 precursor

      See identical proteins and their annotated locations for NP_001100791.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      D3ZKF5
      UniProtKB/TrEMBL
      A0A0G2JZB1
      Related
      ENSRNOP00000070978.2, ENSRNOT00000080084.3
      Conserved Domains (5) summary
      COG0265
      Location:150 → 484
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00987
      Location:391 → 482
      PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
      pfam00219
      Location:44 → 98
      IGFBP; Insulin-like growth factor binding protein
      pfam07648
      Location:121 → 163
      Kazal_2; Kazal-type serine protease inhibitor domain
      pfam13365
      Location:213 → 351
      Trypsin_2; Trypsin-like peptidase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      73704255..73717722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZKF5.1 GenPept UniProtKB/Swiss-Prot:D3ZKF5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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