Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cacna2d3provided by RGD
Full Name: calcium voltage-gated channel auxiliary subunit alpha2delta 3provided by RGD
Primary source: RGD:631361
See related: EnsemblRapid:ENSRNOG00000031287 AllianceGenome:RGD:631361
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables voltage-gated calcium channel activity. Involved in calcium ion transport and cellular response to insulin-like growth factor stimulus. Predicted to be part of voltage-gated calcium channel complex. Predicted to be active in GABA-ergic synapse and presynaptic active zone membrane. Orthologous to human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 175.5), Testes (RPKM 28.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (4105048..4919037, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (4098439..4912498, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (4871348..5795825, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit alpha2delta-1 but not alpha2delta-3.
Title: Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit α(2)δ-1 but not α(2)δ-3.
The expression of the alpha(2)delta(3) calcium channel subunit to multiple cell types suggests that this subunit participates widely in Ca-channel-mediated signaling in the retina.
Title: Expression and cellular localization of the voltage-gated calcium channel α2δ3 in the rodent retina.
all of the alpha(2)delta subunits studied, alpha(2)delta-1, alpha(2)delta-2, and alpha(2)delta-3, show all of the properties expected of glycosylphosphatidylinositol-anchored proteins, both when heterologously expressed and in native tissues.[Cacna2d3
Title: The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function.

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General gene information

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Markers

AU048102 (e-PCR)
- UniSTS:109870

RH133095 (e-PCR)
- UniSTS:216378

Cacna2d3 (e-PCR), detects polymorphism
- UniSTS:495938

d16rat86 (e-PCR)
- UniSTS:121176

D2S339 (e-PCR), detects polymorphism
- UniSTS:42401

AU048875 (e-PCR)
- UniSTS:145325

D16Mit2 (e-PCR), detects polymorphism
- UniSTS:226759

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin-like growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of presynapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: voltage-dependent calcium channel subunit alpha-2/delta-3

Names: calcium channel, voltage-dependent, alpha 2/delta 3 subunit; calcium channel, voltage-dependent, alpha2/delta subunit 3; voltage-gated calcium channel subunit alpha-2/delta-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175595.2 → NP_783185.1 voltage-dependent calcium channel subunit alpha-2/delta-3 precursor

See identical proteins and their annotated locations for NP_783185.1

Status: PROVISIONAL

Source sequence(s)

AF486278

UniProtKB/Swiss-Prot

Q8CFG5

UniProtKB/TrEMBL

F1LSR8

Related

ENSRNOP00000097929.2, ENSRNOT00000117613.2

Conserved Domains (3) summary

cd01463
Location:242 → 425

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

pfam02743
Location:452 → 542

Cache_1; Cache domain

pfam08399
Location:113 → 229

VWA_N; VWA N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

4105048..4919037 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275287.1 → XP_063131357.1 voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X2

UniProtKB/Swiss-Prot

Q8CFG5
XM_063275286.1 → XP_063131356.1 voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1

UniProtKB/TrEMBL

A0A8I6G6W1

Related

ENSRNOP00000042602.5, ENSRNOT00000048043.5
XM_063275289.1 → XP_063131359.1 voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X3