Ccar2 cell cycle and apoptosis regulator 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccar2provided by RGD
Official Full Name: cell cycle and apoptosis regulator 2provided by RGD
Primary source: RGD:1309922
See related: EnsemblRapid:ENSRNOG00000018295 AllianceGenome:RGD:1309922
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309922
Summary: Predicted to enable RNA polymerase II complex binding activity and enzyme inhibitor activity. Predicted to be involved in several processes, including regulation of DNA-templated transcription; regulation of protein metabolic process; and regulation of signal transduction. Predicted to be located in several cellular components, including mitochondrial matrix; nucleoplasm; and spindle. Predicted to be part of DBIRD complex. Predicted to be active in nucleus. Orthologous to human CCAR2 (cell cycle and apoptosis regulator 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Spleen (RPKM 87.4), Thymus (RPKM 72.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p11

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (51622519..51637911, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (45212797..45228001, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (51818887..51834443, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_26825-26826:1034282505:1 (e-PCR)
- UniSTS:269089

AU016692 (e-PCR)
- UniSTS:186010

UniSTS:237223 (e-PCR)
- UniSTS:237223

RH143886 (e-PCR)
- UniSTS:233132

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II complex binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fragmentation involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of catalytic activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA damage checkpoint	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription elongation	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in response to UV	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of DBIRD complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cell cycle and apoptosis regulator protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170472.2 → NP_001163943.1 cell cycle and apoptosis regulator protein 2

See identical proteins and their annotated locations for NP_001163943.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6HTI8, F1LM55

Related

ENSRNOP00000024895.5, ENSRNOT00000024895.9

Conserved Domains (4) summary

COG1196
Location:811 → 917

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK13914
Location:444 → 494

PRK13914; invasion associated endopeptidase

pfam14443
Location:340 → 457

DBC1

pfam14444
Location:55 → 112

S1-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

51622519..51637911 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006252268.5 → XP_006252330.1 cell cycle and apoptosis regulator protein 2 isoform X1

See identical proteins and their annotated locations for XP_006252330.1

UniProtKB/TrEMBL

A6HTI8, F1LM55

Conserved Domains (4) summary

COG1196
Location:811 → 917

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK13914
Location:444 → 494

PRK13914; invasion associated endopeptidase

pfam14443
Location:340 → 457

DBC1

pfam14444
Location:55 → 112

S1-like
XM_017599702.2 → XP_017455191.1 cell cycle and apoptosis regulator protein 2 isoform X2

UniProtKB/TrEMBL

A6HTI8