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    Zdhhc20 zinc finger DHHC-type palmitoyltransferase 20 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305923, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zdhhc20provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 20provided by RGD
    Primary source
    RGD:1305755
    See related
    EnsemblRapid:ENSRNOG00000011024 AllianceGenome:RGD:1305755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305755
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Predicted to be involved in several processes, including peptidyl-L-cysteine S-palmitoylation; positive regulation by host of viral process; and synaptic vesicle maturation. Predicted to be located in Golgi membrane and plasma membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC20 (zinc finger DHHC-type palmitoyltransferase 20). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 174.7), Spleen (RPKM 144.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zdhhc20 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (36095624..36154546, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (31980057..32039006, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (38108886..38165765, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene Sin3A associated protein 18 Neighboring gene spindle and kinetochore associated complex subunit 3 Neighboring gene mitochondrial ribosomal protein L57 Neighboring gene uncharacterized LOC134482124 Neighboring gene mitochondrial calcium uptake 2 Neighboring gene uncharacterized LOC102550095 Neighboring gene fibroblast growth factor 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fatty acyl recognition and transfer by an integral membrane S-acyltransferase. Rana MS, et al. Science, 2018 Jan 12. PMID 29326245, Free PMC Article
    2. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. Ohno Y, et al. Mol Biol Cell, 2012 Dec. PMID 23034182, Free PMC Article
    3. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156467

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation by host of viral process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC20
    Names
    membrane-associated DHHC24 zinc finger protein
    probable palmitoyltransferase ZDHHC20
    zinc finger, DHHC domain containing 20
    zinc finger, DHHC-type containing 20
    NP_001034425.2
    XP_006252134.1
    XP_008768971.1
    XP_008768972.1
    XP_063130338.1
    XP_063130339.1
    XP_063130340.1
    XP_063130341.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039336.2 → NP_001034425.2  palmitoyltransferase ZDHHC20

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      Q2TGI6
      Conserved Domains (1) summary
      cl19890
      Location:16 → 309
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      36095624..36154546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770750.4 → XP_008768972.1  palmitoyltransferase ZDHHC20 isoform X4

      Conserved Domains (1) summary
      cl19890
      Location:75 → 380
      zf-DHHC; DHHC palmitoyltransferase

    2. XM_063274270.1 → XP_063130340.1  palmitoyltransferase ZDHHC20 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A7N7

    3. XM_063274268.1 → XP_063130338.1  palmitoyltransferase ZDHHC20 isoform X3

      Related
      ENSRNOP00000014820.5, ENSRNOT00000014820.5

    4. XM_008770749.4 → XP_008768971.1  palmitoyltransferase ZDHHC20 isoform X2

      UniProtKB/TrEMBL
      F7FM28
      Conserved Domains (1) summary
      cl19890
      Location:75 → 380
      zf-DHHC; DHHC palmitoyltransferase

    5. XM_006252072.5 → XP_006252134.1  palmitoyltransferase ZDHHC20 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AR22, Q2TGI6
      Related
      ENSRNOP00000059785.3, ENSRNOT00000063962.5
      Conserved Domains (1) summary
      cl19890
      Location:75 → 380
      zf-DHHC; DHHC palmitoyltransferase

    6. XM_063274269.1 → XP_063130339.1  palmitoyltransferase ZDHHC20 isoform X5

    7. XM_063274271.1 → XP_063130341.1  palmitoyltransferase ZDHHC20 isoform X7

      UniProtKB/TrEMBL
      E9PT74
    Nucleotide Protein Strain
    Heading Accession and Version

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