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    Urgcp upregulator of cell proliferation [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305493, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Urgcpprovided by RGD
    Official Full Name
    upregulator of cell proliferationprovided by RGD
    Primary source
    RGD:1564681
    See related
    EnsemblRapid:ENSRNOG00000012184 AllianceGenome:RGD:1564681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Urg4; RGD1564681
    Summary
    Predicted to enable GTP binding activity. Predicted to be located in cytosol. Orthologous to human URGCP (upregulator of cell proliferation). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 170.8), Heart (RPKM 164.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Urgcp in Genome Data Viewer
    Location:
    14q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84808616..84852785, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80594637..80638972, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85957726..86002227, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 36 Neighboring gene ribosomal protein L18, pseudogene 8 Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene ubiquitin-conjugating enzyme E2D 4 like, pseudogene 2 Neighboring gene drebrin-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    up-regulator of cell proliferation
    Names
    up-regulated gene 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077660.2 → NP_001071128.1  up-regulator of cell proliferation

      See identical proteins and their annotated locations for NP_001071128.1

      Status: VALIDATED

      Source sequence(s)
      BI285944, DN931704, DN934843, EX490902, FM041979, FM044330, FM046879, FM056971
      UniProtKB/TrEMBL
      A0A096MJ37, A0A8I6AE57, A6IKN3
      Related
      ENSRNOP00000067978.2, ENSRNOT00000076874.4
      Conserved Domains (1) summary
      cl21455
      Location:693 → 793
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      84808616..84852785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273225.1 → XP_063129295.1  up-regulator of cell proliferation isoform X2

      UniProtKB/TrEMBL
      A6IKN4

    2. XM_039092051.2 → XP_038947979.1  up-regulator of cell proliferation isoform X3

      UniProtKB/TrEMBL
      F1M5F4
      Related
      ENSRNOP00000101502.1, ENSRNOT00000165193.1
      Conserved Domains (2) summary
      cl27170
      Location:333 → 466
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:618 → 718
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_006251312.5 → XP_006251374.1  up-regulator of cell proliferation isoform X2

      See identical proteins and their annotated locations for XP_006251374.1

      UniProtKB/TrEMBL
      A6IKN4, F1M5F4
      Conserved Domains (1) summary
      cl21455
      Location:650 → 750
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_039092050.2 → XP_038947978.1  up-regulator of cell proliferation isoform X1

      UniProtKB/TrEMBL
      A0A096MJH4, F1M5F4
      Conserved Domains (2) summary
      cl27170
      Location:391 → 524
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:676 → 776
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_006251315.5 → XP_006251377.1  up-regulator of cell proliferation isoform X2

      See identical proteins and their annotated locations for XP_006251377.1

      UniProtKB/TrEMBL
      A6IKN4, F1M5F4
      Related
      ENSRNOP00000016468.7, ENSRNOT00000016468.7
      Conserved Domains (1) summary
      cl21455
      Location:650 → 750
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    6. XM_063273223.1 → XP_063129293.1  up-regulator of cell proliferation isoform X2

      UniProtKB/TrEMBL
      A6IKN4

    7. XM_039092052.2 → XP_038947980.1  up-regulator of cell proliferation isoform X3

      UniProtKB/TrEMBL
      F1M5F4
      Related
      ENSRNOP00000068129.3, ENSRNOT00000076740.4
      Conserved Domains (2) summary
      cl27170
      Location:333 → 466
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:618 → 718
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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