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    myb v-myb avian myeloblastosis viral oncogene homolog [ Danio rerio (zebrafish) ]

    Gene ID: 30519, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mybprovided by ZNC
    Official Full Name
    v-myb avian myeloblastosis viral oncogene homologprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-991110-14
    See related
    Ensembl:ENSDARG00000053666 AllianceGenome:ZFIN:ZDB-GENE-991110-14
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cmyb; c-myb
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including definitive hemopoiesis; hematopoietic stem cell migration; and regulation of neutrophil differentiation. Is active in chromatin. Is expressed in several structures, including head; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Orthologous to human MYB (MYB proto-oncogene, transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See myb in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (31815423..31830043)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (31888892..31903512)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 8 family, member A1 Neighboring gene HBS1-like translational GTPase Neighboring gene uncharacterized LOC103909697 Neighboring gene mitochondrial fission regulator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Chemically-defined generation of human hemogenic endothelium and definitive hematopoietic progenitor cells. Chang Y, et al. Biomaterials, 2022 Jun. PMID 35567999, Free PMC Article
    2. Temporal-spatial low shear stress induces heterogenous distribution of hematopoietic stem cell budding in zebrafish. Cui Y, et al. Cell Mol Life Sci, 2022 Jul 6. PMID 35792959, Free PMC Article
    3. In Vivo Chemical Screen in Zebrafish Embryos Identifies Regulators of Hematopoiesis Using a Semiautomated Imaging Assay. Arulmozhivarman G, et al. J Biomol Screen, 2016 Oct. PMID 27112172
    4. c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model. Ye Y, et al. Animal Model Exp Med, 2024 Apr. PMID 36300552, Free PMC Article
    5. A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells. Oo ZM, et al. Leuk Lymphoma, 2018 Sep. PMID 29249175, Free PMC Article

    See all (435) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model.
      Title: c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model.
    2. The interaction of Pu.1 and cMyb in zebrafish neutrophil development.
      Title: The interaction of Pu.1 and cMyb in zebrafish neutrophil development.
    3. Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb.
      Title: Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb.
    4. The adult wave of microglia originates from cmyb-dependent hematopoietic stem cells.
      Title: Embryonic Microglia Derive from Primitive Macrophages and Are Replaced by cmyb-Dependent Definitive Microglia in Zebrafish.
    5. Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma.
      Title: Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma.
    6. studies show that merestinib effectively blocks eIF4E phosphorylation in AML cells and suppresses primitive leukemic progenitors from AML patients in vitro and in an AML xenograft model in vivo.
      Title: c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish.
    7. cMyb plays a hitherto unidentified role in dictating physiologic HSPC migration by modulating Sdf1a signaling.
      Title: cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis.
    8. show that knockdown of miR-126 results in increased c-Myb levels and promotes erythropoiesis at the expense of thrombopoiesis in vivo
      Title: Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb.
    9. Results suggest that the key role of c-myb in definitive hematopoiesis is similar to that in mammals and must have become established early in vertebrate evolution.
      Title: Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved.
    10. expression of CD41 and cmyb marks nascent HSCs in the zebrafish AGM, and provide the means to further dissect HSC generation and
      Title: CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chordate embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in hemopoiesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of neutrophil differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of neutrophil differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional activator Myb
    Names
    transcription factor cmyb

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309822.1 → NP_001296751.1  transcriptional activator Myb isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX927365, CT573377
      UniProtKB/TrEMBL
      A0A8M1P6R3, F1QP24
      Related
      ENSDARP00000070211.5, ENSDART00000075730.7
      Conserved Domains (4) summary
      smart00717
      Location:92 → 140
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:92 → 138
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:259 → 303
      LMSTEN; LMSTEN motif
      pfam09316
      Location:417 → 560
      Cmyb_C; C-myb, C-terminal

    2. NM_131266.2 → NP_571341.2  transcriptional activator Myb isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BX927365, CT573377
      UniProtKB/TrEMBL
      A0A8M1PBN3, F1QP25
      Related
      ENSDARP00000070207.4, ENSDART00000075726.5
      Conserved Domains (4) summary
      smart00717
      Location:92 → 140
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:92 → 138
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:259 → 303
      LMSTEN; LMSTEN motif
      pfam09316
      Location:370 → 509
      Cmyb_C; C-myb, C-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      31815423..31830043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395160.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      209987..224129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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