Brdt bromodomain testis associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Brdtprovided by RGD
Official Full Name: bromodomain testis associatedprovided by RGD
Primary source: RGD:1306678
See related: EnsemblRapid:ENSRNOG00000002073 AllianceGenome:RGD:1306678
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable lysine-acetylated histone binding activity and nucleosomal histone binding activity. Involved in chromatin remodeling and spermatogenesis. Located in nucleus. Human ortholog(s) of this gene implicated in azoospermia; oligospermia; and spermatogenic failure 21. Orthologous to human BRDT (bromodomain testis associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 382.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (2532275..2590780, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (2387372..2445857, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (3437876..3462613, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The N terminus of Brdt is involved in the recognition of Smarce1 as well as in the reorganization of hyperacetylated round spermatid chromatin.
Title: Insights into role of bromodomain, testis-specific (Brdt) in acetylated histone H4-dependent chromatin remodeling in mammalian spermiogenesis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone reader activity	IEA Inferred from Electronic Annotation more info
enables histone reader activity	ISO Inferred from Sequence Orthology more info
enables histone reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	IEA Inferred from Electronic Annotation more info
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in male meiosis I	IEA Inferred from Electronic Annotation more info
involved_in male meiosis I	ISO Inferred from Sequence Orthology more info
involved_in male meiosis I	ISS Inferred from Sequence or Structural Similarity more info
involved_in male meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in male meiotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in sperm DNA condensation	IEA Inferred from Electronic Annotation more info
involved_in sperm DNA condensation	ISO Inferred from Sequence Orthology more info
involved_in sperm DNA condensation	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: bromodomain testis-specific protein

Names: bromodomain, testis-specific

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012031.3 → NP_001012031.1 bromodomain testis-specific protein isoform 2

See identical proteins and their annotated locations for NP_001012031.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

Q6AYL3

Conserved Domains (2) summary

cd05497
Location:26 → 132

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cl02556
Location:271 → 322

Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_001402393.1 → NP_001389322.1 bromodomain testis-specific protein isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

D4A7T3

UniProtKB/TrEMBL

A6KPJ9, F7F8G2

Related

ENSRNOP00000058256.3, ENSRNOT00000061538.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

2532275..2590780 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273033.1 → XP_063129103.1 bromodomain testis-specific protein isoform X8

UniProtKB/Swiss-Prot

D4A7T3
XM_063273029.1 → XP_063129099.1 bromodomain testis-specific protein isoform X6

UniProtKB/Swiss-Prot

D4A7T3
XM_063273032.1 → XP_063129102.1 bromodomain testis-specific protein isoform X7

UniProtKB/Swiss-Prot

D4A7T3
XM_063273031.1 → XP_063129101.1 bromodomain testis-specific protein isoform X7

UniProtKB/Swiss-Prot

D4A7T3
XM_063273030.1 → XP_063129100.1 bromodomain testis-specific protein isoform X7

UniProtKB/Swiss-Prot

D4A7T3
XM_063273028.1 → XP_063129098.1 bromodomain testis-specific protein isoform X5

UniProtKB/Swiss-Prot

D4A7T3
XM_063273027.1 → XP_063129097.1 bromodomain testis-specific protein isoform X4

UniProtKB/Swiss-Prot

D4A7T3
XM_063273023.1 → XP_063129093.1 bromodomain testis-specific protein isoform X2

UniProtKB/Swiss-Prot

D4A7T3
XM_063273026.1 → XP_063129096.1 bromodomain testis-specific protein isoform X3

UniProtKB/Swiss-Prot

D4A7T3

UniProtKB/TrEMBL

A6KPJ9, F7F8G2
XM_063273025.1 → XP_063129095.1 bromodomain testis-specific protein isoform X3

UniProtKB/Swiss-Prot

D4A7T3

UniProtKB/TrEMBL

A6KPJ9, F7F8G2
XM_063273024.1 → XP_063129094.1 bromodomain testis-specific protein isoform X3

UniProtKB/Swiss-Prot

D4A7T3

UniProtKB/TrEMBL

A6KPJ9, F7F8G2
XM_063273020.1 → XP_063129090.1 bromodomain testis-specific protein isoform X1

UniProtKB/Swiss-Prot

D4A7T3
XM_063273021.1 → XP_063129091.1 bromodomain testis-specific protein isoform X1

UniProtKB/Swiss-Prot

D4A7T3
XM_063273022.1 → XP_063129092.1 bromodomain testis-specific protein isoform X1

UniProtKB/Swiss-Prot

D4A7T3
XM_063273019.1 → XP_063129089.1 bromodomain testis-specific protein isoform X1

UniProtKB/Swiss-Prot

D4A7T3
XM_063273035.1 → XP_063129105.1 bromodomain testis-specific protein isoform X9

UniProtKB/Swiss-Prot

D4A7T3
XM_063273034.1 → XP_063129104.1 bromodomain testis-specific protein isoform X7

UniProtKB/Swiss-Prot

D4A7T3
XM_063273018.1 → XP_063129088.1 bromodomain testis-specific protein isoform X1

UniProtKB/Swiss-Prot

D4A7T3
XM_063273036.1 → XP_063129106.1 bromodomain testis-specific protein isoform X10