U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Sart3 spliceosome associated factor 3, U4/U6 recycling protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304582, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sart3provided by RGD
    Official Full Name
    spliceosome associated factor 3, U4/U6 recycling proteinprovided by RGD
    Primary source
    RGD:1311646
    See related
    EnsemblRapid:ENSRNOG00000000702 AllianceGenome:RGD:1311646
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone binding activity; snRNA binding activity; and ubiquitin-specific protease binding activity. Predicted to be involved in nucleosome assembly; spliceosomal tri-snRNP complex assembly; and transcription elongation-coupled chromatin remodeling. Predicted to act upstream of or within several processes, including cell morphogenesis; hematopoietic stem cell proliferation; and homeostasis of number of cells. Predicted to be located in Cajal body. Predicted to be part of ASAP complex; U4/U6 snRNP; and U6atac snRNP. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human SART3 (spliceosome associated factor 3, U4/U6 recycling protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 61.4), Spleen (RPKM 52.2) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sart3 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (48519579..48547584)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (42859026..42887041)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (48628198..48656096)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 119 Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene uncharacterized LOC120096010 Neighboring gene FIC domain protein adenylyltransferase Neighboring gene uncharacterized LOC120095862

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP. Damianov A, et al. Mol Cell Biol, 2004 Feb. PMID 14749385, Free PMC Article
    2. Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling. Medenbach J, et al. Mol Cell Biol, 2004 Sep. PMID 15314151, Free PMC Article
    3. Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies. Stanĕk D, et al. J Cell Biol, 2003 Feb 17. PMID 12578909, Free PMC Article
    4. p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor. Bell M, et al. EMBO J, 2002 Jun 3. PMID 12032085, Free PMC Article
    5. TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC. Liu Y, et al. Blood, 2011 May 26. PMID 21447833, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables U4 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U4 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables U6 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U6 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U6atac snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ASAP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4/U6 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT part_of U4atac/U6atac snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U6atac snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    squamous cell carcinoma antigen recognized by T-cells 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107156.1 → NP_001100626.1  squamous cell carcinoma antigen recognized by T-cells 3

      See identical proteins and their annotated locations for NP_001100626.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A6J227
      Related
      ENSRNOP00000104077.1, ENSRNOT00000148999.1
      Conserved Domains (6) summary
      COG5107
      Location:99 → 459
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:703 → 776
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:797 → 877
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam05391
      Location:942 → 959
      Lsm_interact; Lsm interaction motif
      pfam08424
      Location:332 → 485
      NRDE-2; NRDE-2, necessary for RNA interference
      pfam16605
      Location:875 → 933
      LSM_int_assoc; LSM-interacting associated unstructured

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      48519579..48547584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249501.5 → XP_006249563.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

      UniProtKB/TrEMBL
      D3ZAS8
      Related
      ENSRNOP00000000891.4, ENSRNOT00000000891.7
      Conserved Domains (6) summary
      COG5107
      Location:99 → 477
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:721 → 794
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:815 → 895
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam05391
      Location:960 → 977
      Lsm_interact; Lsm interaction motif
      pfam08424
      Location:350 → 503
      NRDE-2; NRDE-2, necessary for RNA interference
      pfam16605
      Location:893 → 951
      LSM_int_assoc; LSM-interacting associated unstructured

    2. XM_006249502.4 → XP_006249564.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X2

      See identical proteins and their annotated locations for XP_006249564.1

      Conserved Domains (6) summary
      COG5107
      Location:4 → 346
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:590 → 663
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:684 → 764
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam05391
      Location:829 → 846
      Lsm_interact; Lsm interaction motif
      pfam08424
      Location:219 → 372
      NRDE-2; NRDE-2, necessary for RNA interference
      pfam16605
      Location:762 → 820
      LSM_int_assoc; LSM-interacting associated unstructured

    3. XM_039089525.2 → XP_038945453.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X3

      Conserved Domains (3) summary
      pfam16605
      Location:488 → 546
      LSM_int_assoc; LSM-interacting associated unstructured
      cd12391
      Location:316 → 389
      RRM1_SART3; RNA recognition motif 1 (RRM1) found in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:410 → 490
      RRM2_SART3; RNA recognition motif 2 (RRM2) found in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools