Tmem119 transmembrane protein 119 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem119provided by RGD
Official Full Name: transmembrane protein 119provided by RGD
Primary source: RGD:1307573
See related: EnsemblRapid:ENSRNOG00000000700 AllianceGenome:RGD:1307573
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307573
Summary: Predicted to be involved in several processes, including endochondral ossification; negative regulation of bone resorption; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within osteoblast differentiation. Predicted to be located in endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human TMEM119 (transmembrane protein 119). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 223.1), Lung (RPKM 93.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (48489157..48496214)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (42828621..42835678)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (48598498..48605704)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d12rat53 (e-PCR)
- UniSTS:120844

RH131188 (e-PCR)
- UniSTS:214471

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in spermatid differentiation	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 119

Names: transmembrane protein 119 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.