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    Tchp trichoplein, keratin filament binding [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304547, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Tchpprovided by RGD
    Official Full Name
    trichoplein, keratin filament bindingprovided by RGD
    Primary source
    RGD:1310813
    See related
    EnsemblRapid:ENSRNOG00000001191 AllianceGenome:RGD:1310813
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310813
    Summary
    Predicted to be involved in apoptotic process; negative regulation of cell growth; and negative regulation of cilium assembly. Predicted to be located in several cellular components, including apical cortex; centrosome; and desmosome. Predicted to be part of ciliary transition fiber. Predicted to be active in keratin filament. Orthologous to human TCHP (trichoplein keratin filament binding). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 184.1), Thymus (RPKM 88.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tchp in Genome Data Viewer
    Location:
    12q16
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47538520..47553895, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41877888..41893264, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47638278..47653602, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 13a Neighboring gene GIT ArfGAP 2 Neighboring gene uncharacterized LOC102547088 Neighboring gene glycolipid transfer protein Neighboring gene transient receptor potential cation channel, subfamily V, member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer. Vecchione A, et al. Oncogene, 2009 Jan 15. PMID 18931701, Free PMC Article
    2. Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. Ibi M, et al. J Cell Sci, 2011 Mar 15. PMID 21325031
    3. Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension. Kasahara K, et al. Nat Commun, 2014 Oct 1. PMID 25270598, Free PMC Article
    4. Identification of trichoplein, a novel keratin filament-binding protein. Nishizawa M, et al. J Cell Sci, 2005 Mar 1. PMID 15731013
    5. Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis. Veleri S, et al. Nat Commun, 2014 Jun 20. PMID 24947469, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ciliary transition fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in desmosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    trichoplein keratin filament-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191666.1 → NP_001178595.1  trichoplein keratin filament-binding protein

      See identical proteins and their annotated locations for NP_001178595.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J1Z0, D3ZY42
      Conserved Domains (1) summary
      pfam13868
      Location:142 → 481
      TPH; Trichohyalin-plectin-homology domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      47538520..47553895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249451.4 → XP_006249513.1  trichoplein keratin filament-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006249513.1

      UniProtKB/TrEMBL
      A6J1Z0, D3ZY42
      Conserved Domains (1) summary
      pfam13868
      Location:142 → 481
      TPH; Trichohyalin-plectin-homology domain

    2. XM_006249452.4 → XP_006249514.1  trichoplein keratin filament-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006249514.1

      UniProtKB/TrEMBL
      A6J1Z0, D3ZY42
      Related
      ENSRNOP00000001577.6, ENSRNOT00000001577.9
      Conserved Domains (1) summary
      pfam13868
      Location:142 → 481
      TPH; Trichohyalin-plectin-homology domain

    3. XM_039089503.2 → XP_038945431.1  trichoplein keratin filament-binding protein isoform X2

      UniProtKB/TrEMBL
      A6J1Z0
      Conserved Domains (1) summary
      pfam13868
      Location:80 → 419
      TPH; Trichohyalin-plectin-homology domain
    Nucleotide Protein Strain
    Heading Accession and Version

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