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    Acad10 acyl-CoA dehydrogenase family, member 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304500, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Acad10provided by RGD
    Official Full Name
    acyl-CoA dehydrogenase family, member 10provided by RGD
    Primary source
    RGD:1310159
    See related
    EnsemblRapid:ENSRNOG00000037815 AllianceGenome:RGD:1310159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310159
    Summary
    Predicted to enable acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Orthologous to human ACAD10 (acyl-CoA dehydrogenase family member 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 319.9), Adrenal (RPKM 247.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acad10 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40561900..40604378)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (34901211..34943973)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40417918..40460562)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ataxin 2 Neighboring gene F-box protein 22, pseudogene 1 Neighboring gene BRCA1 associated protein Neighboring gene aldehyde dehydrogenase 2 family member Neighboring gene MAPK activated protein kinase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187436

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-CoA dehydrogenase family member 10
    Names
    acyl-Coenzyme A dehydrogenase family, member 10
    NP_001385719.1
    XP_038946092.1
    XP_038946093.1
    XP_063127408.1
    XP_063127409.1
    XP_063127410.1
    XP_063127411.1
    XP_063127412.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398790.1 → NP_001385719.1  acyl-CoA dehydrogenase family member 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      B5DEF6, F1LSP2
      Related
      ENSRNOP00000092331.2, ENSRNOT00000104824.2
      Conserved Domains (2) summary
      PLN02876
      Location:257 → 1061
      PLN02876; acyl-CoA dehydrogenase
      TIGR02247
      Location:41 → 247
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      40561900..40604378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271338.1 → XP_063127408.1  acyl-CoA dehydrogenase family member 10 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AV92

    2. XM_039090164.2 → XP_038946092.1  acyl-CoA dehydrogenase family member 10 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AGW1
      Related
      ENSRNOP00000097994.2, ENSRNOT00000096999.2
      Conserved Domains (2) summary
      PLN02876
      Location:257 → 1013
      PLN02876; acyl-CoA dehydrogenase
      TIGR02247
      Location:41 → 247
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

    3. XM_039090165.2 → XP_038946093.1  acyl-CoA dehydrogenase family member 10 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AGW1
      Conserved Domains (2) summary
      PLN02876
      Location:257 → 939
      PLN02876; acyl-CoA dehydrogenase
      TIGR02247
      Location:41 → 247
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

    4. XM_063271339.1 → XP_063127409.1  acyl-CoA dehydrogenase family member 10 isoform X3

    5. XM_063271340.1 → XP_063127410.1  acyl-CoA dehydrogenase family member 10 isoform X5

    6. XM_063271341.1 → XP_063127411.1  acyl-CoA dehydrogenase family member 10 isoform X6

    7. XM_063271342.1 → XP_063127412.1  acyl-CoA dehydrogenase family member 10 isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134537.1: Suppressed sequence

      Description
      NM_001134537.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: ACAD10 (GeneID:80724).
    Nucleotide Protein Strain
    Heading Accession and Version

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