Daglb diacylglycerol lipase, beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Daglbprovided by RGD
Official Full Name: diacylglycerol lipase, betaprovided by RGD
Primary source: RGD:1310193
See related: EnsemblRapid:ENSRNOG00000001079 AllianceGenome:RGD:1310193
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310193
Summary: Predicted to enable monoacylglycerol lipase activity and triacylglycerol lipase activity. Predicted to be involved in several processes, including diacylglycerol catabolic process; positive regulation of triglyceride catabolic process; and unsaturated fatty acid metabolic process. Predicted to act upstream of or within cannabinoid biosynthetic process; monoacylglycerol biosynthetic process; and neuroblast proliferation. Predicted to be located in nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human DAGLB (diacylglycerol lipase beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 74.9), Kidney (RPKM 45.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (16173345..16215777, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (11059732..11102170, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (13113073..13157748, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DAGLbeta is the principal synthesizing enzyme of 2-AG and promotes aggressive phenotype of intrahepatic cholangiocarcinoma via AP-1/DAGLbeta/miR4516 feedforward circuitry.
Title: DAGLβ is the principal synthesizing enzyme of 2-AG and promotes aggressive phenotype of intrahepatic cholangiocarcinoma via AP-1/DAGLβ/miR4516 feedforward circuitry.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134838 (e-PCR)
- UniSTS:218116

RH140945 (e-PCR)
- UniSTS:218116

D12Rat43 (e-PCR)
- UniSTS:118289

UniSTS:498230 (e-PCR)
- UniSTS:498230

Daglb (e-PCR), detects polymorphism
- UniSTS:498230

d12rat34 (e-PCR)
- UniSTS:120828

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipase activity	ISO Inferred from Sequence Orthology more info
enables lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info
enables monoacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables triacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info
enables triacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables triacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in arachidonate metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cannabinoid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cannabinoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in icosanoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in icosanoid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in monoacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoacylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in neuroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: diacylglycerol lipase-beta

Names: DAGL-beta; DGL-beta; PUFA-specific triacylglycerol lipase; sn1-specific diacylglycerol lipase beta

NP_001100590.1

EC 3.1.1.116

EC 3.1.1.3

XP_038945285.1

EC 3.1.1.116

EC 3.1.1.3

XP_038945286.1

EC 3.1.1.116

EC 3.1.1.3

XP_063127326.1

EC 3.1.1.116

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107120.1 → NP_001100590.1 diacylglycerol lipase-beta

See identical proteins and their annotated locations for NP_001100590.1

Status: PROVISIONAL

Source sequence(s)

CH474012

UniProtKB/Swiss-Prot

P0C1S9

UniProtKB/TrEMBL

A0A0U1RRW6, A6K1K9

Related

ENSRNOP00000075840.2, ENSRNOT00000092292.3

Conserved Domains (1) summary

cd00519
Location:274 → 507

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

16173345..16215777 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271256.1 → XP_063127326.1 diacylglycerol lipase-beta isoform X3
XM_039089358.2 → XP_038945286.1 diacylglycerol lipase-beta isoform X2

Conserved Domains (1) summary

cd00519
Location:1 → 226

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
XM_039089357.2 → XP_038945285.1 diacylglycerol lipase-beta isoform X1

Conserved Domains (1) summary

cd00519
Location:274 → 478

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...