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    Fads6 fatty acid desaturase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303671, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fads6provided by RGD
    Official Full Name
    fatty acid desaturase 6provided by RGD
    Primary source
    RGD:1311950
    See related
    EnsemblRapid:ENSRNOG00000021380 AllianceGenome:RGD:1311950
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311950
    Summary
    Predicted to enable oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. Predicted to be involved in lipid metabolic process. Orthologous to human FADS6 (fatty acid desaturase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 569.6), Liver (RPKM 391.8) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fads6 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101020921..101037281, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (100522981..100538181, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103832838..103848035, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor NMDA type subunit 2C Neighboring gene ferredoxin reductase Neighboring gene uncharacterized LOC134480901 Neighboring gene USH1 protein network component sans Neighboring gene otopetrin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid desaturase 6
    Names
    fatty acid desaturase domain family, member 6
    NP_001100534.1
    XP_038942121.1
    XP_038942122.1
    XP_038942123.1
    XP_063125303.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107064.1 → NP_001100534.1  fatty acid desaturase 6

      See identical proteins and their annotated locations for NP_001100534.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HKL5, D3ZEE9
      Related
      ENSRNOP00000036480.4, ENSRNOT00000029001.6
      Conserved Domains (2) summary
      pfam00487
      Location:66 → 311
      FA_desaturase; Fatty acid desaturase
      cl00615
      Location:86 → 301
      Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      101020921..101037281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269233.1 → XP_063125303.1  fatty acid desaturase 6 isoform X1

    2. XM_039086195.2 → XP_038942123.1  fatty acid desaturase 6 isoform X4

      Conserved Domains (1) summary
      cl00615
      Location:91 → 197
      Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...

    3. XM_039086194.2 → XP_038942122.1  fatty acid desaturase 6 isoform X3

      Conserved Domains (1) summary
      cl00615
      Location:95 → 201
      Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...

    4. XM_039086193.2 → XP_038942121.1  fatty acid desaturase 6 isoform X2

      Conserved Domains (1) summary
      cl00615
      Location:100 → 206
      Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...
    Nucleotide Protein Strain
    Heading Accession and Version

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