Epx eosinophil peroxidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Epxprovided by RGD
Official Full Name: eosinophil peroxidaseprovided by RGD
Primary source: RGD:1311882
See related: EnsemblRapid:ENSRNOG00000008707 AllianceGenome:RGD:1311882
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable peroxidase activity. Predicted to be involved in defense response to bacterium. Predicted to act upstream of or within defense response to nematode; eosinophil migration; and regulation of cytokine production. Predicted to be active in extracellular space. Orthologous to human EPX (eosinophil peroxidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 180.1) and Thymus (RPKM 13.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (73164096..73175180, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (72666865..72677952, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (75160690..75171774, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Epx (e-PCR), detects polymorphism
- UniSTS:164920

D10Chm197 (e-PCR)
- UniSTS:518096

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to nematode	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within eosinophil migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: eosinophil peroxidase

NP_001100507.1

EC 1.11.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107037.1 → NP_001100507.1 eosinophil peroxidase precursor

See identical proteins and their annotated locations for NP_001100507.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A6HHW0, D3ZSY4

Related

ENSRNOP00000011735.5, ENSRNOT00000011735.6

Conserved Domains (2) summary

cd09824
Location:287 → 699

myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

pfam03098
Location:145 → 679

An_peroxidase; Animal haem peroxidase