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    Traf4 Tnf receptor associated factor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303285, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Traf4provided by RGD
    Official Full Name
    Tnf receptor associated factor 4provided by RGD
    Primary source
    RGD:1306708
    See related
    EnsemblRapid:ENSRNOG00000013169 AllianceGenome:RGD:1306708
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including WW domain binding activity; enzyme binding activity; and tumor necrosis factor receptor binding activity. Predicted to be involved in cell surface receptor signaling pathway; positive regulation of protein kinase activity; and regulation of intracellular signal transduction. Predicted to act upstream of or within respiratory gaseous exchange by respiratory system and respiratory tube development. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human TRAF4 (TNF receptor associated factor 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 183.1), Kidney (RPKM 164.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Traf4 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63552251..63558356, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63054169..63060284, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65418688..65424802, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Era-like 12S mitochondrial rRNA chaperone 1 Neighboring gene uncharacterized LOC134480829 Neighboring gene family with sequence similarity 222, member B Neighboring gene NIMA-related kinase 8 Neighboring gene TLC domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TRAF Family Member 4 Promotes Cardiac Hypertrophy Through the Activation of the AKT Pathway. Li J, et al. J Am Heart Assoc, 2023 Sep 5. PMID 37642020, Free PMC Article
    2. TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. Rousseau A, et al. PLoS Biol, 2013 Dec. PMID 24311986, Free PMC Article
    3. TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs. Shiels H, et al. Am J Pathol, 2000 Aug. PMID 10934170, Free PMC Article
    4. TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN. Gu X, et al. Cancer Biol Ther, 2007 Dec. PMID 18087216
    5. Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma. Ciribilli Y, et al. Oncotarget, 2017 Nov 24. PMID 29254206, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRAF Family Member 4 Promotes Cardiac Hypertrophy Through the Activation of the AKT Pathway.
      Title: TRAF Family Member 4 Promotes Cardiac Hypertrophy Through the Activation of the AKT Pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioesterase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tumor necrosis factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of NF-kappaB-inducing kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within respiratory tube development ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of plasma membrane signaling receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TNF receptor-associated factor 4
    NP_001100487.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107017.2 → NP_001100487.1  TNF receptor-associated factor 4

      See identical proteins and their annotated locations for NP_001100487.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162047
      UniProtKB/TrEMBL
      A0A8I6AJ00, B1WC90, F7F523
      Related
      ENSRNOP00000018468.4, ENSRNOT00000018468.7
      Conserved Domains (3) summary
      cd03781
      Location:308 → 463
      MATH_TRAF4; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF4 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF4, including the Drosophila protein DTRAF1. TRAF molecules serve as adapter ...
      pfam02176
      Location:210 → 269
      zf-TRAF; TRAF-type zinc finger
      cd16641
      Location:15 → 59
      mRING-HC-C3HC3D_TRAF4; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63552251..63558356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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