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    Telo2 telomere maintenance 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302986, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Telo2provided by RGD
    Official Full Name
    telomere maintenance 2provided by RGD
    Primary source
    RGD:1305553
    See related
    EnsemblRapid:ENSRNOG00000016774 AllianceGenome:RGD:1305553
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305553
    Summary
    Predicted to enable several functions, including Hsp90 protein binding activity; protein kinase binding activity; and telomeric DNA binding activity. Predicted to be involved in 'de novo' cotranslational protein folding and protein stabilization. Predicted to be located in cytoplasm and nuclear body. Predicted to be part of TTT Hsp90 cochaperone complex. Predicted to be active in cytosol. Orthologous to human TELO2 (telomere maintenance 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 83.1), Thymus (RPKM 63.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Telo2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14624998..14640235, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14120491..14135729, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14461581..14476812, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480761 Neighboring gene intraflagellar transport 140 Neighboring gene transmembrane protein 204 Neighboring gene pentraxin 4 Neighboring gene chloride voltage-gated channel 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription. Kamano Y, et al. FEBS Lett, 2013 Oct 11. PMID 24036451
    2. SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. Fernández-Sáiz V, et al. Nat Cell Biol, 2013 Jan. PMID 23263282
    3. mTOR signaling in growth control and disease. Laplante M, et al. Cell, 2012 Apr 13. PMID 22500797, Free PMC Article
    4. CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Horejsí Z, et al. Mol Cell, 2010 Sep 24. PMID 20864032
    5. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' cotranslational protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TTT Hsp90 cochaperone complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    telomere length regulation protein TEL2 homolog
    Names
    TEL2, telomere maintenance 2, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398652.1 → NP_001385581.1  telomere length regulation protein TEL2 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZQ30
      Conserved Domains (1) summary
      pfam10193
      Location:513 → 621
      Telomere_reg-2; Telomere length regulation protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14624998..14640235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268925.1 → XP_063124995.1  telomere length regulation protein TEL2 homolog isoform X2

    2. XM_063268924.1 → XP_063124994.1  telomere length regulation protein TEL2 homolog isoform X1

      UniProtKB/TrEMBL
      D3ZQ30
      Related
      ENSRNOP00000022670.4, ENSRNOT00000022670.8

    3. XM_063268926.1 → XP_063124996.1  telomere length regulation protein TEL2 homolog isoform X3

    4. XM_039087100.1 → XP_038943028.1  telomere length regulation protein TEL2 homolog isoform X4

    5. XM_039087101.2 → XP_038943029.1  telomere length regulation protein TEL2 homolog isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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