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    Tbc1d25 TBC1 domain family, member 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302552, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Tbc1d25provided by RGD
    Official Full Name
    TBC1 domain family, member 25provided by RGD
    Primary source
    RGD:1559711
    See related
    EnsemblRapid:ENSRNOG00000005303 AllianceGenome:RGD:1559711
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Oatl1; RGD1559711
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and regulation of autophagosome maturation. Predicted to be active in autophagosome. Orthologous to human TBC1D25 (TBC1 domain family member 25). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 33.5), Kidney (RPKM 33.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbc1d25 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (16986629..17010228)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14314095..14339171)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15064733..15088579)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene porcupine O-acyltransferase Neighboring gene EBP, cholestenol delta-isomerase Neighboring gene RNA binding motif protein 3 Neighboring gene WD repeat domain 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. Itoh T, et al. J Cell Biol, 2011 Mar 7. PMID 21383079, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TBC1 domain family member 25 protects against myocardial apoptosis and the proinflammatory response triggered by ischemia-reperfusion injury through suppression of the TAK1-JNK/p38 MAPK signaling cascade.
      Title: TBC1 domain family member 25 protects against myocardial apoptosis and the proinflammatory response triggered by ischemia-reperfusion injury through suppression of the TAK1-JNK/p38 MAPK signaling cascade.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 25
    Names
    ornithine aminotransferase-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106955.2 → NP_001100425.1  TBC1 domain family member 25

      See identical proteins and their annotated locations for NP_001100425.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161862
      UniProtKB/TrEMBL
      B1WBS1, F7F8Z1
      Related
      ENSRNOP00000095370.2, ENSRNOT00000099656.2
      Conserved Domains (1) summary
      smart00164
      Location:225 → 454
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      16986629..17010228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601993.3 → XP_017457482.1  TBC1 domain family member 25 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ALA8

    2. XM_063279918.1 → XP_063135988.1  TBC1 domain family member 25 isoform X3

    3. XM_063279917.1 → XP_063135987.1  TBC1 domain family member 25 isoform X3

    4. XM_006256701.5 → XP_006256763.1  TBC1 domain family member 25 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALA8
      Conserved Domains (1) summary
      smart00164
      Location:193 → 422
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein Strain
    Heading Accession and Version

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