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    Ctdspl CTD small phosphatase like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301056, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Ctdsplprovided by RGD
    Official Full Name
    CTD small phosphatase likeprovided by RGD
    Primary source
    RGD:1304841
    See related
    EnsemblRapid:ENSRNOG00000046257 AllianceGenome:RGD:1304841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Orthologous to human CTDSPL (CTD small phosphatase like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 64.5), Kidney (RPKM 60.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ctdspl in Genome Data Viewer
    Location:
    8q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (127520478..127644999)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (118642729..118767238)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (127065292..127726248)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha 9 Neighboring gene uncharacterized LOC134480112 Neighboring gene uncharacterized LOC134480247 Neighboring gene transfer RNA glycine (anticodon ACC) 3 Neighboring gene microRNA 26a Neighboring gene uncharacterized LOC102548352 Neighboring gene villin-like Neighboring gene phospholipase C, delta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays. Dmitriev AA, et al. Epigenetics, 2012 May. PMID 22491060
    2. MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Zhu Y, et al. Nucleic Acids Res, 2012 May. PMID 22210897, Free PMC Article
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CTD small phosphatase-like protein
    Names
    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
    NP_001100335.1
    NP_001382669.1
    XP_038937226.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106865.1 → NP_001100335.1  CTD small phosphatase-like protein isoform 2

      See identical proteins and their annotated locations for NP_001100335.1

      Status: VALIDATED

      Source sequence(s)
      CH473954
      UniProtKB/TrEMBL
      A6I3U6
      Conserved Domains (1) summary
      cl21460
      Location:1 → 108
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_001395740.1 → NP_001382669.1  CTD small phosphatase-like protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      M0R4W4
      Related
      ENSRNOP00000064414.2, ENSRNOT00000075793.4
      Conserved Domains (1) summary
      TIGR02251
      Location:106 → 265
      HIF-SF_euk; Dullard-like phosphatase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      127520478..127644999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081298.2 → XP_038937226.1  CTD small phosphatase-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6GE87
      Related
      ENSRNOP00000111038.1, ENSRNOT00000144382.1
      Conserved Domains (1) summary
      TIGR02251
      Location:95 → 254
      HIF-SF_euk; Dullard-like phosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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