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    ptpn1 protein tyrosine phosphatase non-receptor type 1 [ Danio rerio (zebrafish) ]

    Gene ID: 30081, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ptpn1provided by ZNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980605-23
    See related
    Ensembl:ENSDARG00000007923 AllianceGenome:ZFIN:ZDB-GENE-980605-23
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ptp1b; wu:fk54h03
    Summary
    Predicted to enable non-membrane spanning protein tyrosine phosphatase activity and protein kinase binding activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade and negative regulation of PERK-mediated unfolded protein response. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in early endosome and endoplasmic reticulum. Is expressed in liver. Human ortholog(s) of this gene implicated in coronary artery disease; essential hypertension; and type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See ptpn1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (28398780..28408414, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (28343616..28359201, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene tyrosine-protein phosphatase non-receptor type 1-like Neighboring gene uncharacterized LOC110439998 Neighboring gene uncharacterized LOC110439999 Neighboring gene uncharacterized LOC110440000

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pleiotropic effects of zebrafish protein-tyrosine phosphatase-1B on early embryonic development. van der Sar AM, et al. Int J Dev Biol, 1999 Nov. PMID 10707902
    2. Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson's Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo. Feng CW, et al. Parkinsons Dis, 2020. PMID 33456749, Free PMC Article
    3. VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Lanahan AA, et al. Dev Cell, 2010 May 18. PMID 20434959, Free PMC Article
    4. Effects of chronic dietary selenomethionine exposure on repeat swimming performance, aerobic metabolism and methionine catabolism in adult zebrafish (Danio rerio). Thomas JK, et al. Aquat Toxicol, 2013 Apr 15. PMID 23399444
    5. SOCS1 and SOCS3 are the main negative modulators of the somatotrophic axis in liver of homozygous GH-transgenic zebrafish (Danio rerio). Studzinski AL, et al. Gen Comp Endocrinol, 2009 Mar. PMID 18955058

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of PERK-mediated unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 1
    Names
    protein tyrosine phosphatase 1b
    NP_001300614.1
    NP_001300615.1
    NP_570999.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313685.1 → NP_001300614.1  tyrosine-protein phosphatase non-receptor type 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC049294, CABZ01087208, Y14427
      UniProtKB/TrEMBL
      A0A8M1P706, Q9PT91
      Related
      ENSDARP00000062692.5, ENSDART00000062693.6
      Conserved Domains (2) summary
      smart00194
      Location:1 → 274
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:41 → 274
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_001313686.1 → NP_001300615.1  tyrosine-protein phosphatase non-receptor type 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      CABZ01087208, CABZ01087209
      UniProtKB/TrEMBL
      A0A8M1P706, Q9PT91
      Conserved Domains (2) summary
      smart00194
      Location:1 → 274
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:41 → 274
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    3. NM_130924.3 → NP_570999.2  tyrosine-protein phosphatase non-receptor type 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      CABZ01087208, Y14427
      UniProtKB/TrEMBL
      A0A8M1P706, Q9PT91
      Conserved Domains (2) summary
      smart00194
      Location:1 → 274
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:41 → 274
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      28398780..28408414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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